This review explores organ transplantation, spanning historical developments, psychosocial impacts, and future directions. In the pre-transplantation phase, evaluations of psychosocial factors, including substance use, mental health, and social support, are essential for successful outcomes. However, linking total psychosocial risk scores to post-transplant outcomes remains challenging despite available tools and assessments. Patient selection criteria and psychological assessments are pivotal in achieving successful transplantation outcomes. The age of donors significantly impacts transplant outcomes across various organs, highlighting the urgency of addressing organ shortages. Meticulous patient selection, including thorough psychosocial evaluations, ensures recipients possess the necessary emotional resilience and support systems for successful transplantation. Both pre- and post-transplantation psychological evaluation processes are crucial for assessing and supporting individuals throughout the transplant journey. Posttransplant evaluations continue to monitor adjustment difficulties, medication adherence, and complex emotions, enabling timely intervention and personalized support. The waiting period before transplantation presents significant challenges, including uncertainty, anxiety, and social isolation. Robust emotional support and coping mechanisms are crucial during this transitional phase, fostering resilience and hope among waitlist candidates. Psychological challenges during and after transplantation, including anxiety, depression, and sleep disturbances, are common among recipients. Coping mechanisms, such as religious/spiritual approaches, social support, and participation in support groups, play pivotal roles in patient adjustment and recovery. Ethical considerations are paramount in ensuring fair and effective transplantation practices, including organ allocation, adherence to post-transplant care, financial burdens, and the interplay between medical and psychosocial factors.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850674PMC
http://dx.doi.org/10.1007/s44192-025-00148-yDOI Listing

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