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Murine Aortic Valve Cell Heterogeneity at Birth.
Arterioscler Thromb Vasc Biol
March 2025
Department of Pediatrics, Division of Pediatric Cardiology, Medical College of Wisconsin, Milwaukee (T.B., J.R.K., A.J.K., J.L.).
Background: Heart valve function requires a highly organized ECM (extracellular matrix) network that provides the necessary biomechanical properties needed to withstand pressure changes during each cardiac cycle. Lay down of the valve ECM begins during embryogenesis and continues throughout postnatal stages when it is remodeled into stratified layers and arranged according to blood flow. Alterations in this process can lead to dysfunction and, if left untreated, heart failure.
View Article and Find Full Text PDFSynergistic antifungal effects and mechanisms of amantadine hydrochloride combined with azole antifungal drugs on drug-resistant .
Front Cell Infect Microbiol
March 2025
Infection and Microbiology Research Laboratory for Women and Children, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China.
Introduction: The increasing resistance of () to conventional antifungal drugs poses a great challenge to the clinical treatment of infections caused by this yeast. Drug combinations are a potential therapeutic approach to overcome the drug- resistance of . This study explored the synergistic effects of amantadine hydrochloride (AMH) combined with azole antifungal drugs against drug-resistant and .
View Article and Find Full Text PDFSuccessful Treatment of Recalcitrant Melasma with Picolaser and Isobionicamide-Cysteamine Combination.
J Clin Aesthet Dermatol
February 2025
Dr. Kasraee is with Scientis SA in Geneva, Switzerland and Centre de Dermatologie de Cornavin in Geneva, Switzerland.
Melasma is a highly recurrent disorder that is challenging to treat and significantly affects the quality of life of patients. Cysteamine is an endogenous antioxidant produced during the coenzyme A metabolism cycle and is naturally present in all mammalian cells. The depigmenting efficacy of topical cysteamine has been shown in several double-blind, randomized, placebo-controlled clinical trials.
View Article and Find Full Text PDFDrupacine as a potent SARS-CoV-2 replication inhibitor .
Biosaf Health
October 2024
School of Basic Medical Sciences, Tsinghua University, Beijing 100084, China.
Despite the availability of vaccines and antiviral treatments, the continued emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and breakthrough infections underscores the need for new, potent antiviral therapies. In a previous study, we established a transcription and replication-competent SARS-CoV-2 virus-like particle (trVLP) system that recapitulates the complete viral life cycle. In this study, we combined high-content screening (HCS) with the SARS-CoV-2 trVLP cell culture system, providing a powerful phenotype-oriented approach to assess the antiviral potential of compounds on a large scale.
View Article and Find Full Text PDFBiowaste to biochar: a techno-economic and life cycle assessment of biochar production from food-waste digestate and its agricultural field application.
Biochar
March 2025
Sustainable Process Technologies Research Group, Faculty of Engineering, The University of Nottingham, Nottingham, NG7 2RD UK.
Unlabelled: Biochar has high potential for long-term atmospheric carbon storage in terrestrial environments, contributing to meeting the UK and global greenhouse gas emission reduction targets. This study investigates the greenhouse gas emissions and techno-economics associated with biochar produced from food waste anaerobic digestate using hydrothermal carbonisation followed by high-temperature post carbonisation. Owing to high moisture contents, digestates are challenging to valorise.
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