Purpose Of Review: To summarize the current knowledge on the assessment of gastrointestinal dysfunction.
Recent Findings: Clinical assessment is becoming more structured but remains largely subjective. Some instrumental tools to assess gastrointestinal motility have been developed but not yet widely applied in clinical practice. Imaging techniques offer a good method for static (i.e. nonfunctional) diagnostics but a standardized dynamic assessment at the bedside is currently unavailable. Recent studies on biomarkers have not provided convincing results for accurate evaluation of gastrointestinal function.
Summary: Clinical assessment remains the main tool for assessing gastrointestinal dysfunction. A single sign or symptom does not reflect gastrointestinal dysfunction adequately, and a set of variables might be needed. Studies on tools reflecting gastrointestinal motility and biomarkers for response to enteral nutrients, including absorption, are warranted.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/MCC.0000000000001248 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Efficacy of Linaclotide in Functional Dyspepsia and Constipation-Predominant Irritable Bowel Syndrome Overlap: A Randomized Trial.
J Gastroenterol Hepatol
March 2025
Key Laboratory of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Background And Aim: Linaclotide is effective in relieving constipation-predominant irritable bowel syndrome symptoms. However, few studies focus on the efficacy of linaclotide for overlapping symptoms of functional dyspepsia among irritable bowel syndrome patients. This study aimed to assess the efficacy of linaclotide compared with lactulose in patients with functional dyspepsia and constipation-predominant irritable bowel syndrome overlap.
View Article and Find Full Text PDFA clinical decision support alert to promote timely laxative use in in-patients prescribed clozapine.
BJPsych Open
March 2025
Department of Medicine, University of Otago, Christchurch, New Zealand.
Background: Clozapine-induced gastrointestinal hypomotility and constipation can result in severe and sometimes fatal gastrointestinal complications. Laxatives should be prophylactically prescribed with clozapine, but this is inconsistently achieved. Digital clinical decision support (CDS) alerts can promote safer prescribing.
View Article and Find Full Text PDFEvaluation of gut microbiota alterations following orlistat administration in obese mice.
Front Endocrinol (Lausanne)
March 2025
Department of Endocrinology & Metabolism, Shenzhen University General Hospital, Shenzhen, China.
Background: The gut microbiota plays a pivotal role in various metabolic disorders. Orlistat has shown beneficial effects on weight loss and metabolism, but its direct impact on the gut microbiota has not been extensively reported. Thus, this study aimed to explore the effects of orlistat on the gut microbiota in mice with high-fat diet-induced obesity.
View Article and Find Full Text PDFIntroduction: Cystic fibrosis (CF) is a severe autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. This condition disrupts chloride channels and leads to the production of thick, sticky mucus, affecting the respiratory and gastrointestinal systems. CF's prevalence is particularly high in Saudi Arabia, where the incidence has increased from 1 in 2,000 to 1 in 1,000 births.
View Article and Find Full Text PDFThe Short- and Long-Term Effects of a Short Course of Sauerkraut Supplementation on the Gut Microbiota of Active Athletes: A Pilot Follow-Up Study.
Nutrients
March 2025
Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, 10000 Zagreb, Croatia.
: The application of whole fermented foods in sports nutrition for gut microbiota personalization is a promising area of investigation. Sauerkraut, a traditional fermented food, has not been extensively studied in this context. This study aimed to replicate earlier findings of a proof-of-concept study on the potential of sauerkraut for gut microbiota personalization in active athletes.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!