Dermatosis neglecta (DN) is a rare condition, often linked to psychosomatic disorders, with an unclear etiology. Chilblain lupus erythematosus (CHLE) constitutes a rare variant of cutaneous lupus erythematosus, frequently mistaken for idiopathic chilblain due to its chilblain-like lesions. To date, no instances of concurrent DN and CHLE occurring at the site of a skin flap or graft have been documented. Herein, we present a case that the occurrence of DN and CHLE developed on a skin flap at once. The simultaneous occurrence of DN and CHLE on a skin flap is exceptionally rare. Clinicians must exercise heightened vigilance due to the common misdiagnosis of CHLE. Various skin disorders can manifest on skin flaps and grafts post-transplantation. Thus, clinicians must remain vigilant for both recurrence and metastasis during post-operative monitoring, while also attending to patients' mental well-being and the condition of skin flaps.
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http://dx.doi.org/10.2147/CCID.S509485 | DOI Listing |
Am J Clin Pathol
March 2025
Center for Clinical Studies, LLC, Webster, TX, United States.
Objective: Cutaneous lupus erythematosus (CLE) is a chronic autoimmune disorder of the skin.
Methods: In this report, we describe the case of an African American woman with CLE who had an ulcer on her posterior thigh. Despite this, initial biopsy specimen of the lesion revealed no evidence of CLE until a repeat biopsy 5 months later.
ANZ J Surg
March 2025
Department of Thyroid and Breast Surgery, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China.
Eur J Immunol
March 2025
Division of Rheumatology, Department of Medicine, University of Washington, Seattle, Washington, USA.
Approximately 17% of our genome consists of copies of the retrotransposon "long interspersed element-1" (LINE-1 or L1). Patients with systemic lupus erythematosus (SLE) frequently have autoantibodies against the L1-encoded ORF1 protein (ORF1p), which correlate with disease activity and interferon gene signature. ORF1p is present in neutrophils from patients with active disease in perinuclear ribonucleoprotein particles that also contain Ro60 and nucleic acid sensors.
View Article and Find Full Text PDFAnn Acad Med Singap
February 2025
Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, People's Republic of China.
Introduction: Hydroxychloroquine (HCQ), originally an antimalarial drug, is currently used to treat multiple disorders, especially rheumatic diseases. Given its good efficacy and safety, HCQ is widely administered in pregnant patients. However, the safety profile of HCQ during pregnancy remains controversial due to limited research.
View Article and Find Full Text PDFMed Trop Sante Int
December 2024
Service de médecine interne, CHU de Libreville, BP 2228, Libreville, Gabon.
Background: HIV/AIDS infection is endemic in sub-Saharan Africa. It is manifested by a variety of opportunistic diseases that usually occur when the CD4 count is below 200/mm, but also during the immune restoration syndrome (IRS) that occurs under highly active antiretroviral therapy (HAART). Autoimmune and inflammatory diseases are rarely associated with this condition.
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