Objective: This study aimed to investigate the effect of empowerment-based interventions on self-efficacy and self-care capacity among adults with sickle cell disease (SCD).
Methods: A randomized control trial was conducted [NCT06296654]. A total of 76 patients were recruited by using a cluster sampling technique in the two health centers in Bahrain from February to May 2022 and randomly allocated to the intervention group ( = 38) or control group ( = 38). The intervention group received the empowerment-based intervention implemented through structured small-group discussion sessions, individualized consultations (5A model: assess, advise, agree, assist, and arrange), and follow-up sessions, while the control group received routine health education. The Sickle Cell Self-Efficacy Scale (SCSES) and the Appraisal of the Self-Care Agency Scale-Revised (ASA-R) were measured at baseline and one month after the intervention among two groups of patients.
Results: A total of 68 patients completed the study (36 patients in the intervention group and 32 patients in the control group). After the intervention, the score of SCSES in the intervention group was 37.0 (35.0, 39.8) higher than the control group 28.0 (25.2, 32.0) ( = - 6.121, < 0.001); the score of ASA-R in the intervention group was 61.0 (58.3, 65.0) higher than the control group 49.0 (43.3, 53.0) ( = 0.653, < 0.001).
Conclusion: Adopting the empowerment-based intervention using the 5As model effectively improves self-efficacy and self-care capacity among patients with SCD.
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http://dx.doi.org/10.1016/j.ijnss.2024.12.011 | DOI Listing |
Clin Transl Allergy
March 2025
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Background: This study aimed to comprehensively characterize the gut microbiome and identify individual and grouped gut microbes associated with food allergy (FA) using 16S rRNA gene sequencing.
Methods: Fecal samples were collected from children with IgE-mediated FA and from sex- and age-matched controls. The V3-V4 variable regions of the 16S rRNA gene of the gut microbiome were profiled using next-generation sequencing (Illumina, USA).
Ann Med
December 2025
Department of Assisted Reproductive Centre, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, China.
Background: Butyrate may inhibit SARS-CoV-2 replication and affect the development of COVID-19. However, there have been no systematic comprehensive analyses of the role of butyrate metabolism-related genes (BMRGs) in COVID-19.
Methods: We performed differential expression analysis of BMRGs in the brain, liver and pancreas of COVID-19 patients and controls in GSE157852 and GSE151803.
Eur J Neurosci
March 2025
School of Psychology, University of Auckland, Auckland, New Zealand.
The aim of the study was to determine the test-retest reliability of MMN and LDN recorded to simple speech contrasts in children with listening difficulties. MMN and LDN responses were recorded from Fz and Cz electrodes for a /da/-/ga/ contrast twice within a 10-day period. To extract MMN and LDN, auditory-evoked responses to /ga/ stimuli presented alone were subtracted from the responses to /ga/ presented within an oddball sequence.
View Article and Find Full Text PDFAnn Med
December 2025
Department of Pulmonary and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Background: Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous condition with different risk factors, including family history. This study aimed to explore association between a family history of chronic airway disease and features and outcomes of COPD.
Methods: Participants were obtained from the RealDTC study between December 2016 and December 2022.
ACS Appl Mater Interfaces
March 2025
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China.
Developing vapor-solid reaction methods to prepare organic-inorganic hybrid perovskite thin films is highly compatible with processes in crystalline silicon solar cells and the thin-film photovoltaic industries, facilitating rapid industrialization. In the vapor-solid reaction, the crystallization quality of perovskite thin films is widely influenced by the crystallinity and microstructure of lead iodide (PbI) precursor films. During the thermal evaporation process of preparing the PbI precursor films, we observed that PbI tends to develop a disordered surface morphology and exhibits high crystallinity, which significantly hinders the uniform diffusion of the organic amine salt vapor during the subsequent vapor-solid reaction.
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