Introduction: The L., a perennial dioecious herb renowned for its industrial applications, serves as the source of hemp. Cannabidiol (CBD), a non-psychotropic compound derived from industrial hemp, has garnered considerable interest due to its promising therapeutic potential.
Methods: The extraction parameters for CBD from industrial hemp were optimized using the Box-Behnken design and response surface methodology (RSM). The purification process involved characterizing the penetration and desorption profiles of CBD on HPD-100 resin. The antibacterial activity was assessed by determining the minimum inhibitory concentration (MIC) against and . Antioxidant properties were evaluated using DPPH and ABTS assays, as well as an iron-reducing ability test.
Results: After optimization, the extraction rate of CBD reached 0.26 ± 0.02%. The use of HP-100 resin in the purification process resulted in a significant enrichment of CBD content, which was 4.2 times higher than that of the crude extract, with a recovery rate of 83.13%. The MIC against was found to be 5 mg/mL, while no inhibitory effect was observed against . The IC50 values for the DPPH and ABTS assays were 0.1875 mg/mL and 2.988 mg/mL, respectively, indicating the potent antioxidant capacity of CBD. Additionally, CBD demonstrated a strong iron-reducing ability.
Conclusion: These findings contribute to the development of CBD for broader applications in various industries, highlighting its potential as a valuable compound in health and wellness sectors.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842326 | PMC |
| http://dx.doi.org/10.3389/fpls.2025.1495779 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
High strength kami-ito yarns from microbial cellulose biofilms.
Int J Biol Macromol
March 2025
Bioproducts Institute, The University of British Columbia, 2385 East Mall, Vancouver, BC V6T 1Z4, Canada; Department of Chemical and Biological Engineering, University of British Columbia, 2360 East Mall, Vancouver, BC V6T 1Z3, Canada; Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada; Department of Wood Science, University of British Columbia, 2424 Main Mall, Vancouver, BC V6T 1Z4, Canada.. Electronic address:
We present a method for developing high-strength, sustainable yarns from microbial biofilms with minimal processing and chemical use. Inspired by the japanese "kami-ito" () technique for creating yarns from paper, we introduce an eco-friendly alternative to cotton and industrially-produced man-made cellulose fibers using a microbial cellulose source. We culture and dye bacterial cellulose biofilms that we used to produce yarns with tensile strengths of up to 200 MPa (55 MPa in the wet state).
View Article and Find Full Text PDFSelectivity of herbicides applied in the post-emergence of industrial hemp ( L.).
J Environ Sci Health B
March 2025
Center of Nuclear Energy in Agriculture, University of São Paulo, Piracicaba, Brazil.
The objective of this study was to evaluate the selectivity of four post-emergence herbicides in the cultivation of industrial hemp. Hemp was grown in 3.5 L pots with inert substrate in the absence of weeds throughout the crop cycle.
View Article and Find Full Text PDFFabrication and evaluation of stationary phases with different morphology from two imidazole-based ligands for nonchiral and chiral electrochromatographic separation.
Talanta
March 2025
Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, Interdisciplinary Research Academy (IRA), Zhejiang Shuren University, Hangzhou, 310000, China. Electronic address:
In this work, two metal-organic porous materials from the two imidazole-based ligands (4-methylimidazole-5-carbaldehyde (aImeIm) and histidine (His)) and the same metal source (Zn(CHCOO)·2HO), namely His-ZIF-93 with a crystal zeolite imidazolate framework and His/aImeIm@Zn with an amorphous networks, were first designed and synthesized by the one-pot method. They were used as the stationary phases (SPs) of open-tubular capillary electrochromatography (OT-CEC) to evaluate and compare their separation performance for the nonchiral and chiral compounds. His-ZIF-93-bonded OT-CEC column successfully separated five families of nonchiral analytes due to the synergistic effect of His and the crystal framework.
View Article and Find Full Text PDFThe Canadian Lung Outcomes in Users of Vaping Devices (CLOUD) Study: protocol for a prospective, observational cohort study.
BMJ Open
March 2025
Centre for Heart Lung Innovation, The University of British Columbia, Vancouver, British Columbia, Canada
Introduction: The rapid growth in popularity of e-cigarettes over the past decade has prompted concerns about their impact on long-term respiratory health. Small airway injury is suspected to be a direct consequence of e-cigarette use and may be quantifiable by novel structural and functional diagnostic modalities.
Methods And Analysis: In a multicentre observational longitudinal study, participants will be enrolled in either an adolescent (ages ≥12 and <19 years) or an adult arm (≥19 years old) and followed over 3 years across three time points (baseline, 18 months and 36 months).
Evaluation of cannabis-derived anti-inflammatory and analgesic treatment in animals and identification of cannabinoid-based effective inhibition of prostaglandin through computational studies.
J Biomol Struct Dyn
March 2025
Pakistan Council of Scientific and Industrial Research (PCSIR), Islamabad, Pakistan.
Many medical conditions are accompanied by severe pain. Acute pain refers to the experience of pain that lasts for only a few hours, whereas chronic pain is the ongoing emergence of pain signals over an extended period. Since ancient times, cannabis has been utilized for medical purposes.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!