F-FDG (fluorodeoxyglucose) accumulates in malignant tissues but also at the sites of infection and inflammation and in autoimmune and granulomatous diseases by the overexpression of distinct facultative glucose transporter (GLUT) isotypes (mainly GLUT-1 and GLUT-3) in cancer cells and inflammatory cells. A 75-year-old female with a history of skin rash with tenderness for 1 month underwent F-FDG positron emission tomography/computed tomography (PET/CT) to determine the presence of an underlying disease including malignant tumor. The F-FDG PET/CT showed hypermetabolic nodules at subcutaneous tissue (right upper arm, bilateral lower back and buttock, both thigh). She was diagnosed with erythema induratum on biopsy.
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http://dx.doi.org/10.1016/j.radcr.2025.01.067 | DOI Listing |
Pancreatic ductal adenocarcinoma (PDAC) is highly susceptible to metastasis, making early detection of metastases and associated risk factors crucial for effective management. This study aimed to assess the performance of fluorine (F)- fibroblast activation protein inhibitor-04 (F-FAPI-04) positron emission tomography/computed tomography (PET/CT) in detecting metastasis and predicting pathological characteristics and risk factors in 67 PDAC patients. Comparisons were made with F-fluorodeoxyglucose (F-FDG) PET/CT.
View Article and Find Full Text PDFSci Rep
March 2025
Department of Nuclear Medicine, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, 1071 Anyangcheon‑ro, Yangcheon‑gu, Seoul, 07985, Republic of Korea.
Breast cancer occurs at a younger age compared to western countries in South Korea. Despite advancements in treatment methods such as targeted therapy and immunotherapy, the increasing number of patients underscores the importance of improving disease-free survival (DFS). In this study, we evaluated the associations between gut microbiota composition, inflammatory cytokine levels, and breast cancer recurrence in preoperative patients.
View Article and Find Full Text PDFJ Physiol Biochem
March 2025
Centro de Investigación Biomédica en Red Fisiopatología de La Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Background: Soluble Alpha-Klotho (S-αklotho) protein and 25-Hydroxyvitamin D (25-OH-D) have emerged as potential modulators for activating and recruiting Brown Adipose Tissue (BAT). The present study aimed to investigate whether circulating S-αklotho and 25-OH-D levels are related to BAT volume, Fluorine-Fluorodeoxyglucose (F-FDG) uptake, and BAT radiodensity in young healthy adults.
Methods: A total of 128 participants (68% women) aged 18-25 years old participated in this cross-sectional study.
Semin Nucl Med
March 2025
Department of Radiation Oncology, LMU University Hospital, LMU Munich, Munich, Germany. Electronic address:
In the clinical management of lung cancer, radiotherapy remains a cornerstone of multimodal treatment strategies, often used alongside surgery or in combination with systemic therapies such as chemotherapy, tyrosine kinase inhibitors, and immune checkpoint inhibitors. While conventional imaging modalities like computed tomography (CT) and magnetic resonance imaging (MRI) continue to play a central role in staging, response assessment, and radiotherapy planning, advanced imaging techniques, particularly [F]FDG PET/CT, are being increasingly integrated into routine clinical practice. These advanced techniques address the limitations of standard imaging by providing insight into molecular and metabolic tumor characteristics, enabling precise tumor visualization, accurate target volume delineation, and early treatment response assessment.
View Article and Find Full Text PDFRev Esp Med Nucl Imagen Mol (Engl Ed)
March 2025
Servicio de Medicina Nuclear, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Grupo de Imagen Molecular (IDIVAL), Santander, Cantabria, Spain.
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