Objective: This observational study aims to comprehensively explore the network relationship and mechanism of action between cognitive function and quality of life among community-dwelling older adults aged 60 and above in Beijing.
Methods: The research encompassed a cohort of 323 older adults individuals residing in the community in Beijing. Data were collected from January to July 2024 using convenience sampling. Cognitive function was evaluated using the Chinese adaptation of the Montreal Cognitive Assessment (MoCA), while quality of life was assessed through the Medical Outcomes Study 36-Item Short-Form Health Survey version 2 (SF-36v2). Cognitive assessment involved seven dimensions, namely visuospatial/executive function, naming, attention, language, abstraction, delayed recall, and orientation. Concurrently, quality of life was assessed across eight dimensions: physical functioning, role physical, bodily pain, general health, vitality, social functioning, role emotional, and mental health. Network analysis graphs were developed to investigate the interrelationships among variables, identify central nodes, and evaluate stability.
Results: In the network, the dimensions of social functioning, role-physical, physical functioning, general health, vitality, orientation, and language showed high centrality strength. The dimensions of physical functioning, role-physical, language, and orientation exhibited strong closeness and betweenness. There were strong associations between role-physical and social functioning, physical functioning and role-physical, and vitality and mental health. The centrality stability coefficients for strength, closeness, and betweenness were 0.672, 0.672, and 0.285, respectively.
Conclusion: The network structure was stable, indicating that dimensions such as social functioning, role-physical, and physical functioning play pivotal roles influencing cognitive function in community-dwelling older adults. Orientation and language were the most representative dimensions of cognitive function and may serve as important targets for interventions aimed at improving cognitive function and subsequently enhancing QoL. These findings provide practical guidance for community health interventions. Future research should explore causal relationships and develop scalable strategies to support aging populations.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842236 | PMC |
http://dx.doi.org/10.3389/fpubh.2024.1516895 | DOI Listing |
JAMA Netw Open
March 2025
Department of Psychiatry, University of Oxford, Oxford, United Kingdom.
Importance: Epidemiological studies suggest that lifestyle factors are associated with risk of dementia. However, few studies have examined the association of diet and waist to hip ratio (WHR) with hippocampus connectivity and cognitive health.
Objective: To ascertain how longitudinal changes in diet quality and WHR during midlife are associated with hippocampal connectivity and cognitive function in later life.
JAMA Psychiatry
March 2025
Institute of Behavioral Science, Feinstein Institutes for Medical Research, Manhasset, New York.
Importance: Peripheral (blood-based) biomarkers for psychiatric illness could benefit diagnosis and treatment, but research to date has typically been low throughput, and traditional case-control studies are subject to potential confounds of treatment and other exposures. Large-scale 2-sample mendelian randomization (MR) can examine the potentially causal impact of circulating proteins on neuropsychiatric phenotypes without these confounds.
Objective: To identify circulating proteins associated with risk for schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD) as well as cognitive task performance (CTP).
Aging Dis
February 2025
Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Studies have linked inhalation anesthesia and surgery to increased cognitive impairment, particularly in the elderly. Our previous research showed that isoflurane, but not desflurane, affected cognitive function in mice by modulating cyclophilin D (CypD), a key regulator of the mitochondrial permeability transition pore (mPTP) and mitochondrial function. Both anesthetics metabolize into trifluoroacetic acid (TFA), which is associated with cognitive deficits.
View Article and Find Full Text PDFAging Dis
March 2025
First Clinical Medical College, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Recent advances in microbial pathogen research have highlighted the potential of gut microbe-based microbial medicine. One of the most extensively studied biological pathways is the gut-brain axis, which has been shown to reverse neurological disorders. Evidence from animal-based studies of dysbiosis suggest complex behavioral changes, such as alterations in sociability and anxiety, can be modulated through gut microbiota.
View Article and Find Full Text PDFAging Dis
March 2025
Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California 90095, USA.
Aging leads to a decline in physiological functions and increased risk of mortality, yet therapeutic avenues are limited. Dietary phytochemicals provide an attractive approach to counteract age-related health decline. Here, we have examined the impact of feeding extracts of rosemary and ginger, prepared via three different extraction methods, on markers of aging and healthspan in the fruit fly Drosophila.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!