Photothermal therapy (PTT) presents unique advantages, including high temporal and spatial controllability and relatively few toxic side effects. Active targeting modifications of photothermal agents can deliver nanoprobes to tumors more efficiently, reducing toxic side effects while improving efficacy. In this work, the polyphenols, gallic acid, folic acid (FA), hyaluronic acid (HA), and Fe(III) were selected to prepare a self-photothermal nanoplatform Ga/Fe/HA/FA based on polyphenol-metal self-assembly. The self-assembly process synchronously integrated the targeting molecules, folic acid and hyaluronic acid, layer by layer in a polyphenol-metal network, thus realizing the "layer-by-layer targeting" effect. Compared with the traditional targeting modification, the self-assembly multitargeting modification strategy effectively avoided the complicated experimental steps of traditional targeting modification. Meanwhile, it mitigated the off-target risk during blood circulation and improved tumor-targeting efficiency, ultimately augmenting the effectiveness of photothermal therapy.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11840619 | PMC |
| http://dx.doi.org/10.1021/acsomega.4c07611 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Synergistic photothermal-sonodynamic therapy for antibacterial and immune reprogramming in chronic osteomyelitis.
J Control Release
March 2025
Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China. Electronic address:
The development of antibiotic resistance and inadequate immune response in chronic inflammation pose significant challenges in treating chronic osteomyelitis. As accepted non-antibiotic antimicrobial therapies, sonodynamic therapy (SDT) and photothermal therapy (PTT) are recognized for their effectiveness in eliminating bacteria and promoting tissue repair, rendering them promising therapeutic strategies for treating bacterial infections and preventing the emergence of drug-resistant bacteria. However, the antimicrobial action and efficacy in promoting tissue repair depend on the activation status of the host immune system.
View Article and Find Full Text PDFNext generation of porphysomes for improved photodynamic therapy applications.
J Control Release
March 2025
Université Paris-Saclay, CNRS, Institut Galien Paris-Saclay, Bâtiment Henri Moissan, 17, Avenue des Sciences, 91400 Orsay, France. Electronic address:
Porphysomes are a class of liposome-like nanoparticles that have demonstrated efficacy in photothermal therapy (PTT) and photodynamic therapy (PDT) against cancer. These nanoparticles results from the self-assembly of amphiphilic phospholipid-porphyrin (PL-Por) conjugates. Despite their potential, porphysomes exhibit a high photothermal effect and a weak photodynamic activity as long as they remain intact within the body.
View Article and Find Full Text PDFNear-infrared light triggered bio-inspired enhanced natural silk fibroin nanofiber composite scaffold for photothermal therapy of periodontitis.
Colloids Surf B Biointerfaces
March 2025
Department of stomatology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215000, China. Electronic address:
Periodontitis is one of the major oral health issues worldwide, with significant impacts on oral health and patients's quality of life, but current therapies have not achieved optimal regeneration of periodontal tissue. This study developed scaffolds using natural tussah silk fibroin (TSF) cross-linked with regenerated silk fibroin (SF) nanofibers to improve mechanical properties and wet-state stability. Zinc oxide (ZnO) and polydopamine (PDA) composite nanoparticles were loaded into scaffold to impart its antibacterial and photothermal properties to construct a photo-responsive composite scaffold (ZnO/PDA/TSF-SF).
View Article and Find Full Text PDFMolecular Engineering of a SICTERS Small Molecule with Superior Raman Imaging and Photothermal Performance.
J Am Chem Soc
March 2025
Department of Pharmacology and Chemical Biology, Institute of Molecular Medicine, Collaborative Innovation Center for Clinical and Translational Science by Chinese Ministry of Education & Shanghai, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Raman-based theranostics has demonstrated great potential for sensitive real-time imaging and treatment. However, these advanced materials, primarily depending on the SERS technique, encounter clinical concerns regarding substrate biosafety. Herein, we molecularly engineered a substrate-free SICTERS small molecule, namely BTT-TPA (bis-thienyl-substituted benzotriazole selenadiazole derivative structures), possessing both ultrasensitive Raman signals and excellent photothermal effects based on self-stacking.
View Article and Find Full Text PDFDiagnostic and Therapeutic Potential of Photo-Responsive Nanomaterials in Osteoarthritis.
Aging Dis
March 2025
Medical School of Chinese PLA, Beijing, China.
Osteoarthritis (OA) is the most common musculoskeletal disease globally and is the main reason for the chronic pain and disability in people over sixty-five worldwide. Degradation of the articular cartilage, synovial inflammation and osteophyte formation are widely acknowledged as the primary pathological manifestations of OA. OA affects more than 300 million people all over the world, bringing extremely large socioeconomic burden.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!