Introduction: Chronic respiratory symptoms (dyspnoea, coughing, sputum production) associated with abnormalities of the airways (bronchitis, bronchiolitis) and/or alveoli (emphysema) that result in persistent, frequently progressive airflow obstruction are the hallmarks of COPD, a diverse lung illness. The current investigation aimed to establish a clinical profile of patients with recently diagnosed COPD who present to a healthcare facility in Vadodara.
Materials And Methods: The Department of Respiratory Medicine conducted an observational cross-section study on individuals with recently discovered COPD. The study comprised records of 50 participants, from September 2022 to January 2024. Along with the spirometry results, pertinent clinical data were gathered.
Results: The study's patient population presented with an average age of 61.52 years. The fact that every patient in the research was over 40 years old suggests that COPD is becoming more common in people over 40. There was a male majority among the 50 patients, with 40 (80%) male and 10 (20%) female. Most common age group was smokers accounted for 80% of the total cases, suggesting that their incidence of COPD is greater. Average FEV1 at presentation was 41 L/min for 50 patients. Among 50 patients, 6% falls under mild, 28% under moderate, 42% under severe, and 24% under very severe according to GOLD grading and severity of airflow obstruction.
Conclusion: Despite the fact that tobacco smoke is thought to be the main cause of COPD. Indoor and outdoor air pollution are major issues in many nations, including India. One of the main risk factors for COPD is smoke from activities such as burning wood or biomass fuels in addition to work exposure. The ageing of the global population and ongoing exposure to COPD risk factors are expected to contribute to a rise in the prevalence and burden of COPD in the ensuing decades. The fact that most newly diagnosed patients in this research were older and more symptomatic and that most identified individuals had moderate to severe COPD, indicates the importance of spirometry programs in primary care for the early detection of COPD. Our findings suggest that a new campaign requiring patients to undergo spirometry and routine follow-up may be able to identify a sizable proportion of patients with undiagnosed COPD and perhaps improve their quality of life.
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http://dx.doi.org/10.4103/jfmpc.jfmpc_836_24 | DOI Listing |
Clinicoecon Outcomes Res
March 2025
CliCon S.r.l., Società Benefit, Health, Economics & Outcomes Research, Bologna, 40137, Italy.
Purpose: To describe patients with hormone receptor positive and human epidermal growth factor receptor 2 negative metastatic breast cancer (HR+/HER2- mBC) in Italy for demographic and clinical variables, comorbidity profile, metastases and therapeutic pathways.
Patients And Methods: From 2017 to 2021, HR+/HER2- mBC patients were extrapolated from administrative databases of healthcare entities covering a catchment area of about 3 million health-assisted women. The study included patients with a hospital discharge diagnosis for mBC; with specific prescriptions of therapies for HR+; without HER2-targeted therapy; with at least one prescription for CDK4/6 inhibitors.
Int J Chron Obstruct Pulmon Dis
March 2025
College of Basic Medical Sciences, Jilin University, Changchun, 130021, People's Republic of China.
COPD is a multifactorial illness characterized by a long-term restriction of airflow and an inflammatory reaction in the lungs. The associated emphysema leads to the breakdown of alveolar proteins and abnormal expansion of the lung air spaces. Chronic bronchitis caused by the same disease can result in increased deposition of structural proteins, narrowing of the airways, and excessive mucus secretion leading to acute exacerbation of COPD (AECOPD).
View Article and Find Full Text PDFInt J Chron Obstruct Pulmon Dis
March 2025
Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden, Lund University, Lund, Sweden.
Background: Severe alpha-1-antitrypsin deficiency (AATD) is a known risk factor for early development of emphysema and COPD. By the Swedish national screening program within the years 1972-74 a cohort of individuals with severe AATD (PiZZ) was identified and regularly followed up. The aim of this study was to investigate alveolar volume (V) and the ratio V/Total lung capacity (V/TLC) for the detection of signs of hyperinflation and ventilation heterogeneity in PiZZ individuals compared with an age-matched control group (phenotype PiMM), randomly selected from the population registry.
View Article and Find Full Text PDFBackground: Chronic obstructive pulmonary disease (COPD) has become a major global healthcare issue due to its high prevalence and mortality rates. Increasing evidence suggests that autophagy plays a role in the development of COPD, yet there is a lack of bibliometric analyses on literature related to autophagy and COPD. Therefore, this study aims to summarize the current research status, research direction, and research hotspots in the literature related to COPD and autophagy.
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