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Mathematical analysis of long-distance polar auxin transport data of pin mutants questions the role of PIN1 as postulated in the chemi-osmotic theory.
Physiol Plant
March 2025
Plant Biodynamics Laboratory and Department of Plant Developmental Genetics, Institute of Biology Leiden, Leiden University, Leiden, The Netherlands.
The plant hormone auxin (Indole-3-Acetic Acid, IAA) is a key player in nearly every aspect of plant growth and development ranging from cell division and cell elongation to embryogenesis and root formation. The IAA level in specific tissues and cells is regulated by synthesis, conjugation, degradation and transport. Especially long-range polar auxin transport (PAT) has been the subject of numerous studies.
View Article and Find Full Text PDFDevelopment of a multi-epitope vaccine candidate to combat SARS-CoV-2 and dengue virus co-infection through an immunoinformatic approach.
Front Immunol
March 2025
Division of Metabolomics, Proteomics & Imaging facility, Regional Medical Research Centre, Indian Council of Medical Research (ICMR), Dibrugarh, Assam, India.
Background: Although the SARS-CoV-2 and dengue viruses seriously endanger human health, there is presently no vaccine that can stop a person from contracting both viruses at the same time. In this study, four antigens from SARS-CoV-2 and dengue virus were tested for immunogenicity, antigenicity, allergenicity, and toxicity and chosen to predict dominant T- and B-cell epitopes.
Methods: For designing a multi-epitope vaccine, the sequences were retrieved, and using bioinformatics and immunoinformatics, the physicochemical and immunological properties, as well as secondary structures, of the vaccine were predicted and studied.
Collective escape waves provide a generic defence against different avian predators.
R Soc Open Sci
March 2025
Department of Biology and Ecology of Fishes, Leibniz-Institute of Freshwater Ecology and Inland Fisheries, Müggelseedamm 310, Berlin 12587, Germany.
In many animal species, collective behaviours can be explained by a simple set of interaction rules. It is an intriguing question whether this generality at the level of mechanism also translates into generality at the level of function. Assuming that collective behaviour provides antipredator benefits for the partaking individuals, we ask whether the same collective behaviour provides protection against different predators in general.
View Article and Find Full Text PDFCyberbiosecurity: Advancements in DNA-based information security.
Biosaf Health
August 2024
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.
Synthetic biology is a crucial component of the "cyber-biological revolution" in this new industrial revolution. Owing to breakthroughs in synthetic biology, deoxyribonucleic acid (DNA), the storehouse of hereditary material in biological systems, can now be used as a medium for storage (synthesis) and reading (sequencing) of information. However, integrating synthetic biology with computerization has also caused cyberbiosecurity concerns, encompassing biosecurity and information security issues.
View Article and Find Full Text PDFGenome-wide analysis of family genes in and the role of in copper, zinc tolerance.
Front Plant Sci
February 2025
Biotechnology Research Institute, Shanghai Academy of Agricultural Sciences, Shanghai, China.
12-oxo-phytodienoic acid reductase (OPR) is one of the key enzymes in the octadecanoid pathway, and it controls the last step of jasmonic acid (JA) biosynthesis. Although multiple isoforms and functions of s have been identified in various plants, no genes have been identified, and their possible roles in grapevine development and defense mechanisms remain unknown. In this study, nine genes were identified from grapevine genome and classified into two subfamilies.
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