Advancements in the treatment of keratinocyte carcinoma have broadened therapeutic opportunities for patients who elect to avoid surgery or are poor surgical candidates. Due to this evolving landscape of pharmacologic (topical, intralesional or systemic), photodynamic, laser and radiation based, and minimally-invasive treatments (either field-directed, lesion-directed, and/or systemic), providers may be faced with uncertainty in selecting an optimal alternative to surgical care. Part 2 of this CME will outline established and emerging evidence-based treatment and preventive therapies for keratinocyte carcinoma to guide care for patients with surgical contraindications.
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http://dx.doi.org/10.1016/j.jaad.2024.10.130 | DOI Listing |
JID Innov
May 2025
Department of Dermatology, Alfred Health, Melbourne, Australia.
Dystrophic epidermolysis bullosa (DEB) is a hereditary skin fragility disease characterized by the loss or dysfunction of collagen VII, predisposing patients to dermal-epidermal separation. This disease is highly associated with the development of progressive fibrosis of the skin and other organs and the occurrence of lethal cutaneous squamous cell carcinomas (cSCCs). These are not only caused by chronic wounding but also by collagen VII deficiency, which may directly alter cellular responses.
View Article and Find Full Text PDFTissue Cell
February 2025
Department of Morphology, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil. Electronic address:
The objective of this research is to perform a cellular morphometric analysis, identify nuclear malignant keratinocyte irregularities, compare the immunoexpression of interleukin-4 (IL-4) and investigate neoplastic invasion depth in Lower Lip Squamous Cell Carcinoma (LLSCC) and Oral Tongue Squamous Cell Carcinoma (OTSCC) cases. A total of 60 cases were analyzed (30 on the lower lip and 30 on the oral tongue). Concerning the cellular morphometry analysis, 16 malignant keratinocytes from each case were analyzed.
View Article and Find Full Text PDFJAMA Dermatol
March 2025
Department of Dermatology, Copenhagen University Hospital-Bispebjerg and Frederiksberg, Copenhagen, Denmark.
Importance: The substantial morbidity and socioeconomic costs associated with actinic keratosis (AK) management represent major public health concerns. Anecdotal evidence suggests that human papillomavirus (HPV) vaccination may offer therapeutic and preventive effects against AK and keratinocyte carcinomas (KCs).
Objective: To investigate the effect of HPV vaccination on burden of disease in immunocompetent patients with high numbers of AK.
J Biomed Opt
March 2025
Université de Lorraine, CNRS, CRAN UMR, Vandoeuvre-Lès-Nancy, France.
Significance: The incidence of keratinocyte carcinomas (KCs) is increasing every year, making the task of developing new methods for KC early diagnosis of utmost medical and economical importance.
Aim: We aim to evaluate the KC diagnostic aid performance of an optical spectroscopy device associated with a machine-learning classification method.
Approach: We present the classification performance of autofluorescence and diffuse reflectance optical spectra obtained from 131 patients on four histological classes: basal cell carcinoma (BCC), squamous cell carcinoma (SCC), actinic keratosis (AK), and healthy (H) skin.
J Am Acad Dermatol
March 2025
Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address:
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