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Hyperhidrosis after COVID-19 infection. | LitMetric

Hyperhidrosis after COVID-19 infection.

Arch Dermatol Res

Department of Dermatology, Wayne State University School of Medicine, Grand Rapids, MI, USA.

Published: February 2025

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Source
http://dx.doi.org/10.1007/s00403-025-03992-8DOI Listing

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Article Synopsis
  • This study investigates how the COVID-19 pandemic negatively impacted the ability of patients to receive iontophoresis treatment for hyperhidrosis, a condition that causes excessive sweating.
  • It is a retrospective analysis conducted in Romania that reviewed data from 111 patients treated between 2013 and 2023, revealing a complete drop in patient visits during the pandemic.
  • The study highlights that despite the debilitating effects of hyperhidrosis on quality of life, patients and their families often do not see it as a pressing health issue needing immediate treatment.
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Early in the pandemic, clinicians recognized an overlap between Long COVID symptoms and dysautonomia, suggesting autonomic nervous system (ANS) dysfunction. Our clinical experience at Johns Hopkins with primary dysautonomia suggested heritability of sympathetic dysfunction, manifesting primarily as hyperhidrosis and as other dysautonomia symptoms. Whole exome sequencing revealed mutations in genes regulating electrical signaling in the nervous system, thus providing a genetic basis for the sympathetic overdrive observed.

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