In response to the article "Evaluation of Cardiac Function in Children Undergoing Liver Transplantation" by Bansal et al., I admire the authors for their valuable insights in evaluating biventricular heart function in pediatric patients undergoing Liver Transplantation. However, I bring up several key concerns regarding study's methodology. The diversity of the pediatric cirrhosis population is limited by the study's small sample size, which consists of only 35 children patients. Advanced diagnostic techniques including tissue Doppler echocardiography and cardiovascular magnetic resonance (CMR), which are valuable for diagnosis of heart diseases, are not included in the study. The lack of a reference group of patients without cirrhosis makes it more difficult to confirm whether the cardiac dysfunction shown is unique to cirrhosis or indicates other chronic disease. Additionally, the study does not provides information regarding the outcomes following liver transplantation especially reversibility of cardaic abnormalities.
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http://dx.doi.org/10.1007/s00246-025-03804-w | DOI Listing |
Pediatr Infect Dis J
March 2025
Department of Pediatrics and Intensive Care Medicine.
Background: To evaluate the disease burden, risk of complications and mortality in children with viral detection during the peri-liver transplant period.
Methods: A retrospective cohort study was conducted between January 2020 and December 2023 at a tertiary university hospital. Children who underwent multiplex polymerase chain reaction testing from 7 days before to 14 days after liver transplantation were included.
Proc Natl Acad Sci U S A
March 2025
Department of Hepatobiliary and Pancreatic Surgery and Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
Chronic infections with hepatitis E virus (HEV), especially those of genotype 3 (G3), frequently lead to liver fibrosis and cirrhosis in patients. However, the causation and mechanism of liver fibrosis triggered by chronic HEV infection remain poorly understood. Here, we found that the viral multiple-domain replicase (ORF1) undergoes unique ubiquitin-proteasomal processing leading to formation of the EV-erived MAD ctivator (HDSA), a viral polypeptide lacking putative helicase and RNA polymerase domains.
View Article and Find Full Text PDFIndian J Gastroenterol
March 2025
Departments of Pediatrics, Giza, Egypt.
Background And Objectives: Kasai-portoenterostomy (KPE) is the initial attempt to restore the bile flow and salvage the native liver in biliary atresia (BA) patients. Cholangitis is a frequent complication after KPE and adequate treatment impacts the long-term outcome. The aim of our study is to assess the severity of cholangitis episodes in a cohort of BA patients post KPE, identify the causative agents, using several diagnostic methods, as well as to assess the tolerability and efficacy of our antimicrobial protocol.
View Article and Find Full Text PDFCancer Chemother Pharmacol
March 2025
Medical Oncology, Department of Clinical and Molecular Sciences, University Politecnica delle Marche, Ancona, 60126, Italy.
In recent years, assessing dihydropyrimidine dehydrogenase (DPD) activity has become crucial for cancer patients undergoing 5-fluorouracil (5FU)-based chemotherapy due to the life-threatening toxicity associated with reduced DPD function. The methods for evaluating DPD activity have evolved, with the analysis of DPYD polymorphisms in blood samples becoming the preferred approach. As the indications for liver transplantation are increasing-particularly due to a rise in cases of cholangiocarcinoma (CCA) and non-resectable colorectal liver metastasis-more cancer patients with a history of liver transplantation may experience disease relapse.
View Article and Find Full Text PDFLiver Transpl
March 2025
Organ Transplantation Center, National Center for Child Health and Development, Tokyo, Japan.
Background: Despite multiple techniques, portal vein (PV) inflow reconstruction during living donor liver transplantation (LDLT) for patients with biliary atresia (BA) and small-diameter PV remains a challenge. The use of PV interposition grafts has emerged as a promising therapeutic strategy to mitigate complications and reinterventions.
Methods: We conducted a retrospective multi-center cohort study of patients under 3 years of age (n=85) undergoing LDLT for biliary atresia using PV interposition grafts.
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