This report presents the anatomical and histopathological findings observed in a 5 month old Domestic Short Hair cat euthanized owing to long-lasting pelvic limb paralysis. Paralysis occurred after a lumbosacral epidural injection for perioperative pain management during femoral fracture repair. A lumbosacral epidural injection was performed according to established veterinary recommendations, with no immediate complications noted during surgery. On postoperative examinations, the cat had severe pelvic limb neurological deficits, which did not improve over the 6 week follow-up period. Necropsy revealed a traumatic spinal cord injury attributed to needle insertion. Histopathological examination revealed reactive gliosis, axonal degeneration and fibroblasts adjacent to the needle track, significantly altering its architecture. This report underlines the potential risks of spinal cord injury during epidural injections at spinal levels containing the spinal cord. Although there is considerable worldwide experience with lumbosacral epidurals in cats, further studies are needed to better define the risks associated with this procedure, considering anatomical and developmental differences in this species.
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http://dx.doi.org/10.1016/j.vaa.2024.11.003 | DOI Listing |
Global Spine J
March 2025
Combined Neurosurgical and Orthopaedic Spine Program, University of British Columbia, Vancouver, BC, Canada.
Study DesignNarrative Review.ObjectivesTo summarize the work of the AO Spine Knowledge Forum Tumor, specifically studies from the Epidemiology, Process and Outcomes in Spine Oncology (EPOSO) study.MethodsA narrative review of all published manuscripts from the EPOSO study was undertaken.
View Article and Find Full Text PDFDisabil Health J
March 2025
School of Psychology, The University of Adelaide, SA, 5000, Australia.
Background: The importance of health literacy in personal health management is widely recognised in the general population, yet remains poorly understood in some patient groups, including people with spinal cord injury or disorder (SCI/D).
Objectives: The systematic review had two objectives: (1) to determine the health literacy levels of individuals with SCI/D, and (2) to identify facilitators and barriers to developing health literacy in this group.
Methods: Seven databases (CINAHL, Embase, Emcare, ProQuest, PsycINFO, PubMed, and Web of Science) were searched from inception, with an updated search completed on January 21, 2025.
Handb Clin Neurol
March 2025
Donders Institute for Brain Cognition Behaviour, Radboud University, Nijmegen, The Netherlands; Brain Connectivity and Behaviour Laboratory, Sorbonne Universities, Paris, France; Centre for Neuroimaging Sciences, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands. Electronic address:
The human brain is an intricate network of cortical regions interconnected by white matter pathways, dynamically supporting cognitive functions. While cortical asymmetries have been consistently reported, the asymmetry of white matter connections remains less explored. This chapter provides a brief overview of asymmetries observed at the cortical, subcortical, cytoarchitectural, and receptor levels before exploring the detailed connectional anatomy of the human brain.
View Article and Find Full Text PDFZhong Nan Da Xue Xue Bao Yi Xue Ban
October 2024
Department of Anesthesiology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing 210008.
Objectives: Sleep deprivation (SD) is a risk factor for the development of chronic pain in adolescents, significantly affecting pain management and prognosis; however, the mechanisms by which SD influences postoperative pain outcomes remain unclear. This study aims to investigate the molecular mechanism through which the spinal 5-hydroxytryptamine 1 receptor (5-HT1R) regulates the excitation/inhibition (E/I) balance in the dorsal horn to modulate postoperative chronic pain induced by SD in adolescent mice.
Methods: A pain model combining 4.
Int J Biol Macromol
March 2025
Department of Rheumatism and Immunology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China.
Chronic pain is a significant public health concern that diminishes patients' quality of life and imposes considerable socioeconomic costs. Effective pharmacological treatments for ongoing pain are limited. Recent studies have indicated that various models of chronic pain-such as neuropathic pain, inflammatory pain, and pain associated with cancer-have abnormal levels of long noncoding RNAs (lncRNAs).
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