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FEN1-assisted LAMP for specific and multiplex detection of pathogens associated with community-acquired pneumonia.
Analyst
March 2025
Department of Laboratory Medicine, Key Laboratory of Clinical Laboratory Technology for Precision Medicine, School of Medical Technology and Engineering, Fujian Medical University, Fuzhou 350005, China.
Lower respiratory tract infections (LRITs), including community-acquired pneumonia (CAP), are the fifth leading cause of death worldwide over the last ten years, posing a serious threat to global healthcare. Conventional laboratory assays for detecting pathogens are hindered by complicated procedures, a long turnaround time and a lack of multiplex detection capabilities. In this study, a flap-endonuclease 1 (FEN1)-assisted loop-mediated isothermal amplification (LAMP) method was designed, and an assay based on this method was developed to identify three leading pathogens for CAP, namely, , and .
View Article and Find Full Text PDFDNAH9 variants in children with post-infectious bronchiolitis/bronchitis obliterans.
Orphanet J Rare Dis
March 2025
Department II of Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Post-infectious bronchiolitis/bronchitis obliterans (PIBO) is a chronic irreversible obstructive lung disease that results in obstruction and/or obliteration of small airways. Previous reports have indicated that PCD-related gene mutations contribute to PIBO incidence. However, the relationship between DNAH9 variants and PIBO remains unclear.
View Article and Find Full Text PDFRhinovirus and Mycoplasma pneumoniae Co-infection in Pediatric Patients: Atypical Presentations With Renal Complications.
Pediatr Infect Dis J
April 2025
Division of Nephrology, Department of Pediatrics, Denizli State Hospital, Denizli, Turkey.
From Conventional Detection to Point-of-care Tests (POCT) Method for Pediatric Respiratory Infections Diagnosis: A Systematic Review.
Arch Iran Med
February 2025
Pediatric Infectious Diseases Research Center (PIDRC), Tehran University of Medical Sciences, Tehran, Iran.
Bacterial respiratory infections pose significant health risks to children, particularly infants susceptible to upper respiratory tract infections (URTIs). The COVID-19 pandemic has further exacerbated the prevalence of these infections, with pathogens such as and commonly implicated in pediatric cases. The critical need for accurate and timely detection of these bacterial agents has highlighted the importance of advanced diagnostic techniques, including multiplex real-time PCR, in clinical practice.
View Article and Find Full Text PDFNeutrophils are involved in the development and outcomes of plastic bronchitis associated with Mycoplasma pneumoniae pneumonia.
Respir Res
March 2025
Department of Respiratory Medicine, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China.
Background: Previous research has demonstrated a notable increase in neutrophil counts among pediatric patients with plastic bronchitis (PB) associated with Mycoplasma pneumoniae pneumonia (MPP). However, the role of neutrophils in MPP-associated PB remains largely elusive.
Methods: This is a nested case-control study that enrolled patients diagnosed with MPP who underwent bronchoscopy in our department during the MPP pandemic from September 2023 to January 2024.
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