Purpose: This study aimed to assess the thickness and stiffness of the Achilles tendon in patients with primary hyperparathyroidism and compare these findings with those of healthy individuals.
Methods: Bilateral Achilles tendons of 28 patients with primary hyperparathyroidism and 28 healthy controls were evaluated using ultrasound (US) and shear wave elastography (SWE). Tendon thickness was measured with gray-scale US, while stiffness was assessed using SWE, expressed as shear wave velocity (SWV) in meters per second. US and SWE findings were statistically compared between the two groups.
Results: The mean Achilles tendon thickness in patients with primary hyperparathyroidism (right Achilles: 5.07 ± 0.84 mm, left Achilles: 5.16 ± 0.79 mm) did not differ significantly from that in healthy controls (right Achilles: 5.01 ± 0.50 mm, left Achilles: 4.96 ± 0.44 mm; p = 0.757 and p = 0.237 respectively). Similarly, no significant difference was observed in tendon SWV between patients (right: 8.00 ± 1.01 m/s, left: 7.85 ± 1.16 m/s) and controls (right: 7.71 ± 0.95 m/s, left: 7.36 ± 0.97 m/s; p = 0.270 and p = 0.089). Additionally, no correlation was found between serum parathyroid hormone or calcium levels and tendon stiffness (p = 0.889-p = 0.902).
Conclusion: Primary hyperparathyroidism does not appear to influence the thickness or stiffness of the Achilles tendon when compared to healthy individuals.
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http://dx.doi.org/10.1002/jcu.23944 | DOI Listing |
Best Pract Res Clin Endocrinol Metab
March 2025
Division of Endocrinology and Metabolism, McMaster University, Hamilton, ON, Canada. Electronic address:
Persistent and recurrent primary hyperparathyroidism (PHPT) represent significant challenges in the management of PHPT. Persistent PHPT is defined as persistence of hypercalcemia following parathyroidectomy (PTX) or the recurrence of hypercalcemia within the first 6 months following surgery. Recurrent PHPT is defined as recurrence of hypercalcemia after 6 months following PTX and requires normalization of serum calcium prior to the recurrence.
View Article and Find Full Text PDFBalkan J Med Genet
December 2024
Laboratory of Medical Biology - Genetics, Faculty of Medicine, School of Health Sciences, Aristotle University, Thessaloniki, Greece.
Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterized by the overactivity of the parathyroid glands. While a few genes have been linked to a predisposition for PHPT, the genetic foundation of the disease remains unclear, despite it being the third most prevalent endocrine disorder. This pilot study aimed to investigate, for the first time, the potential association between specific variants in Annexin A2 (-rs7170178, rs17191344, rs11633032), Mediator Complex Subunit 12 (-rs1057519912), Calmodulin 1 (-rs12885713), and Mitogen-Activated Protein Kinase 1 (-rs1057519911) genes with PHPT.
View Article and Find Full Text PDFIndian J Otolaryngol Head Neck Surg
February 2025
Department of General Surgery, Amrita Institute of Medical Sciences, Amrita Hospitals, Kochi, Kerala India.
Despite the popularity of auto analyzers in urban areas of the country the incidence of asymptomatic hyperparathyroidism has not markedly increased and symptomatic diseases are regularly seen in all major institutions. The present single-institution analysis of proven hyperparathyroidism in the last 16 years was aimed at comparing the demographic, clinical, and pathological characteristics of symptomatic and asymptomatic primary hyperparathyroidism and comparing those with the asymptomatic diseases seen in developed countries. A retrospective chart review of 332 patients was done and 29 (8.
View Article and Find Full Text PDFEur J Endocrinol
March 2025
Department of Medicine, Division of Nephrology and Hypertension, University Hospitals of Geneva, Geneva, Switzerland.
Introduction: Primary hyperparathyroidism (PHPT) often causes hypercalcemia and complications requiring parathyroidectomy (PTX). Anemia affects 15-50% of PHPT patients, but its mechanisms remain unclear. While parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) contribute to anemia in secondary hyperparathyroidism (SHPT) through erythropoietin (EPO) resistance and bone marrow fibrosis, their roles in PHPT are less defined.
View Article and Find Full Text PDFHeliyon
February 2025
Environmental Science and Technology Research Center, Department of Environmental Health Engineering, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Per- and Poly-fluoroalkyl substances (PFASs) are among the substances that have been widely employed across the world due to their distinct features. These chemicals' great stability in the environment and capacity to be released from consumer goods have demonstrated their existence in all matrices. Additionally, the world's attention has been drawn to these substances' direct relation to human health in recent years.
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