The G3BP1 RNP complex at focal adhesion tunes cell migration.

Trends Cell Biol

School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China. Electronic address:

Published: March 2025

Ribonucleoprotein (RNP) complexes can form multiple mesoscale assemblies, including stress granules (SGs). However, the function and regulation of the soluble RNP complexes are not fully understood. A recent study by Boraas et al. showed that G3BP1, a key node in SG formation, forms focal adhesion (FA)-localized RNP complexes and regulates cell migration.

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http://dx.doi.org/10.1016/j.tcb.2025.02.001DOI Listing

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