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Adrenomedullin Inhibits the Efficacy of Combined Immunotherapy and Targeted Therapy in Biliary Tract Cancer by Disrupting Endothelial Cell Functions.
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Hepatobiliary Center, the First Affiliated Hospital of Nanjing Medical University & Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, Nanjing, Jiangsu, China.
The global incidence of biliary tract cancer (BTC) is on the rise, presenting a substantial healthcare challenge. The integration of immune checkpoint inhibitors (ICIs) with molecularly targeted therapies is emerging as a strategy to enhance immune responses. However, the efficacy and underlying mechanisms of these treatments in BTC are still largely unexplored.
View Article and Find Full Text PDFComparison of Early Functional Recovery Following Triportal Robot-Assisted and Uniportal Video-Assisted Segmentectomy in Patients With Early-Stage Non-Small Cell Lung Cancer: A Propensity Score-Matched Analysis.
Thorac Cancer
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Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong First Medical University, Jinan, P. R. China.
Background: Robot-assisted thoracoscopic surgery (RATS) is more precise and flexible than video-assisted thoracoscopic surgery (VATS) for early-stage non-small cell lung cancer (NSCLC) treatment. This study compared the early postoperative functional recovery of patients who underwent triportal RATS with that of patients who underwent uniportal video-assisted thoracic surgery (UVATS) for segmentectomy.
Methods: This observational, prospective study included 172 patients with clinical stage I or II peripheral NSCLC who underwent RATS or UVATS segmentectomy.
A review in analytical progress for house dust mite allergens.
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Key Laboratory of Environment Remediation and Ecological Health, Ministry of Education, College of Natural Resources and Environmental Science, Zhejiang University, Hangzhou, China.
House dust mite (HDM) allergens are one of the most important causes of allergenic diseases in the indoor environment. The World Health Organization (WHO) has defined risk thresholds for Group I HDM allergens as a concentration of 2 and 10 μg/mL in dust for producing asthma risk and polar asthma attacks, respectively. Continuing exposure to high concentrations of HDM allergens greatly increases the risk of developing allergic diseases.
View Article and Find Full Text PDFEffects of reading augmented reality storybook versus normal storybook reading on preoperative fear and anxiety levels of children in the age group of 7-12 years: A randomized controlled trial.
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Manisa Celal Bayar University, Faculty of Health Sciences, Department of Nursing, Turkey. Electronic address:
Aim And Objectives: In the preoperative period, non-pharmacological methods such as multimedia applications and visual and audio technological tools are used to reduce children's fear and anxiety levels and to distract their attention to create a more enjoyable experience. One of these innovative technologies having attracted attention recently is augmented reality technology. The study was aimed investigating the effects of reading an augmented reality storybook on fear and anxiety levels of children in the age group of 7-12 years in the preoperative period.
View Article and Find Full Text PDFInnovations in red blood cell preservation.
Blood Rev
March 2025
Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada; Innovation and Portfolio Management, Canadian Blood Services, Edmonton, Alberta, Canada. Electronic address:
The global infrastructure supporting nearly 100 million transfusions annually relies on the ability to store red cell concentrates (RCCs) for up to 42 days at hypothermic temperatures or indefinitely at low sub-zero temperatures. While these methods are generally effective, there is both an opportunity and, in specific settings, a need to refine storage techniques that have remained largely unchanged since the 1980s. Recent research has identified ways to address limitations that were not fully understood when these methods were first implemented in blood banks, with much of it focusing on modifying conventional storage strategies, while some studies explore alternative approaches.
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