Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s11357-025-01509-9 | DOI Listing |
Publication Analysis
Top Keywords
international consortium
4
consortium classify
4
classify ageing-related
4
ageing-related pathologies
4
pathologies iccarp
4
iccarp senescence
4
senescence definitions
4
definitions achieving
4
achieving international
4
international consensus
4
Similar Publications
A Comparison of Ten Polygenic Score Methods for Psychiatric Disorders Applied Across Multiple Cohorts.
Biol Psychiatry
November 2021
Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. Electronic address:
Article Synopsis
- Polygenic scores (PGSs) are tools used to estimate genetic risk for diseases by analyzing various DNA variants and their impact, with methods differing in the variants included and how they are weighted.
- The Psychiatric Genomics Consortium evaluated PGS methods for schizophrenia and major depressive disorder using large case-control cohorts, highlighting the effectiveness of different scoring methods in predicting disease risk.
- Results showed that more advanced methods (MegaPRS, LDpred2, SBayesR) significantly outperformed the baseline method, improving prediction accuracy for schizophrenia and major depressive disorder, suggesting their preference for future research and applications.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!