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Infectious diseases, cardio-cerebrovascular health and vaccines: pathways to prevention.
Aging Clin Exp Res
March 2025
National Research Council, Neuroscience Institute, Aging Branch, Padova, Italy.
Cardiovascular and infectious diseases both feature among the leading causes of death among men and women in the world. The pathophysiological pathways of infection and cardiovascular disease intersect, and there is a bidirectional relationship between the two. Vaccines are available for the most common infectious diseases affecting older adults, such as influenza, pertussis, pneumococcal disease, herpes zoster, COVID and respiratory syncytial virus (RSV).
View Article and Find Full Text PDFExecutive Summary of the Delaware State Health Assessment:: 2022-2023 Report.
Dela J Public Health
December 2024
Genetic evidence of methotrexate's protective role against Parkinson's disease: A Mendelian randomization and co-localization study.
Int Immunopharmacol
March 2025
State Key Laboratory of Traditional Chinese Medicine Syndrome, The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510405, China; Department of Rheumatology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, China; Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou, China. Electronic address:
Background: Recent research has indicated a possible link between the use of methotrexate (MTX) and a heightened risk of developing Parkinson's disease (PD). Nevertheless, the causal relationship between MTX and PD continues to be unclear. This study aimed to explore the potential causal impact of MTX use on the risk of PD by employing two-sample Mendelian randomization (MR) alongside co-localization (COLOC) analysis.
View Article and Find Full Text PDFMitigating effects of H3 receptor antagonism on cerebellar autophagic pathways and behavioral phenotypes in BTBR T+ tf/J mouse model of autism spectrum disorder.
Eur J Pharmacol
March 2025
Department of Pharmacology & Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 15551, Al Ain, United Arab Emirates; Zayed Center for Health Sciences, United Arab Emirates University, P.O. Box 15551, Al Ain United Arab Emirates. Electronic address:
Accumulation of evidence suggested the involvement of autophagic pathways and their associated AktmTOR (mammalian target of rapamycin) signalling cascade in the pathogenesis of autism spectrum disorder (ASD). Histamine 3 receptors antagonism may be neuroprotective in ASD, as autophagy is reported to be impaired in ASD. Therefore, the effects the novel H3 receptor antagonist E169 (2.
View Article and Find Full Text PDFLong-term effects of yoga-based practices on neural, cognitive, psychological, and physiological outcomes in adults: a scoping review and evidence map.
BMC Complement Med Ther
March 2025
Department of Basic Psychological Processes, Institute of Psychology, University of Brasilia, Brasilia, Brazil.
Background: Compared with short-term practices, long-term yoga might promote differential qualitative and quantitative outcomes. Following JBI's and PRISMA-ScR guidelines, this scoping review followed an apriori and systematic protocol to document the long-term effects of yoga on neural, cognitive, psychological, and physiological outcomes, provide evidence maps for each yoga component, and summarize results identifying knowledge gaps and promising directions.
Methods: Four databases (PubMed, Cochrane, LILACS, and PubPsych) were last searched in March 2023.
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