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The PP2A-B56 Binding Site LxxIxE Contributes to Asp-Mediated Spindle Pole Stability.
Cytoskeleton (Hoboken)
March 2025
Biology Department, Mount Saint Vincent University, Halifax, Canada.
The organization of microtubules into a mitotic spindle is critical for animal cell proliferation and involves the cooperation of hundreds of proteins whose molecular roles and regulation are not fully understood. The protein product of the Drosophila gene abnormal spindle, Asp, is a microtubule-associated protein required for correct mitotic spindle formation. To better understand the contribution of Asp to microtubule organization during spindle formation, we reverse-engineered flies to express a version of Asp (Asp), predicted to have lost its ability to bind the phosphatase trimer PP2A-B56.
View Article and Find Full Text PDFCharging and Aggregation of Nano-Clay Na-Montmorillonite in the Presence of Ciprofloxacin.
Nanomaterials (Basel)
March 2025
Institute of Life and Environmental Sciences, University of Tsukuba, Tsukuba 305-8572, Ibaraki, Japan.
The transport and fate of antibiotics are significantly influenced by co-existing colloidal and nanosized substances, such as clay particles. Montmorillonite, a common clay mineral with a thin nano-sheet-like structure, enhances antibiotic (e.g.
View Article and Find Full Text PDFNovel, multimodal, simulation practice with evolving case scenario for teaching familial communications in undergraduate medical training.
Med Teach
March 2025
Centre for Healthcare Simulation, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
There is a growing recognition of the importance of familial involvement in patient care. In Asian societies, communications with patients' families for routine medical updates and shared decision-making are considered part-and-parcel of clinical practice. Yet, training in familial communications has remained, by and far, a neglected aspect of conventional communications skills training in the medical curriculum, despite distinctive nuances in the communications approach.
View Article and Find Full Text PDFRobust Assessments of Lithium Mining Impacts Embodied in Global Supply Chain Require Spatially Explicit Analyses.
Environ Sci Technol
March 2025
Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14853, United States.
Lithium is a critical material for the energy transition, but its mining causes significant environmental impacts that will intensify due to surging global demand. Here, we conduct a mining site-specific environmental impact assessment of lithium on a global scale, focusing on greenhouse gas (GHG) emissions, water use, and land use. We then track the production and international trade flows of all lithium-containing commodities to assess how lithium mining impacts are distributed across global supply chains.
View Article and Find Full Text PDFDevelopment and Validation of Machine Learning Models for Outcome Prediction in Patients with Poor-Grade Aneurysmal Subarachnoid Hemorrhage Following Endovascular Treatment.
Ther Clin Risk Manag
March 2025
Department of Neurosurgery, The second Affiliated Hospital, Jiangxi Medical College of Nanchang University, Nanchang, 330006, People's Republic of China.
Background: Endovascular treatment (EVT) has been recommended as a superior modality for the treatment of intracranial aneurysm. However, there still exists a worse percentage of poor functional outcome in patients with poor-grade aneurysmal subarachnoid hemorrhage (aSAH) undergoing EVT. Therefore, it is urgently needed to investigate the risk factors and develop a critical decision model in the subtype of such patients.
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