Editors' selections from the current scientific literature.
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MYC networks associate with decreased CD8 T-cell presence in diffuse large B-cell lymphoma and may be addressed by the synergistic combination of AZD4573 and Selinexor - a preliminary analysis.
Ann Hematol
March 2025
Department of Biological Sciences, Minnesota State University Mankato, Mankato, USA.
Article Synopsis
- Diffuse Large B-cell Lymphoma (DLBCL) is a complex disease affecting over 70,000 patients annually, facing treatment challenges despite advancements in therapies like CAR-T.
- Recent findings highlight the importance of genomic alterations, particularly MYC amplification, which is linked to poor responses to CAR-T therapy, and reveal potential new treatment targets associated with this condition.
- Noteworthy genes were identified that are significantly lost in patients with high MYC levels and poor event-free survival, suggesting the need for customized treatment strategies to improve outcomes in these patients.
Writing an impactful Review: top tips from the Editors.
J Mater Chem B
March 2025
Ohio State University, USA.
Review articles are critical to the scientific enterprise. They are often the starting point for researchers exploring a new area or those searching for a quick overview of the field. Good reviews serve as references for years to come and can be crucial teaching tools.
View Article and Find Full Text PDFPublication of scientific and biomedical manuscripts in "high impact factor" (IF) journals is important in advancing careers, obtaining funding, and developing a field of research. Rejection by prestigious journals is not infrequent and usually painful, especially to young investigators. Reasons provided by an editor are often confusing.
View Article and Find Full Text PDFThe Limited Impact of Randomized Controlled Trials on the Management of Greater Trochanteric Pain Syndrome as Demonstrated by Fragility Indices: A Citation Analysis.
J ISAKOS
March 2025
Division of Orthopaedic Surgery, Department of Surgery, 1200 Main Street West, McMaster University, Hamilton, Ontario, L8N 3Z5, Canada. Electronic address:
Importance: Greater trochanteric pain syndrome (GTPS) is a chronic condition commonly defined as pain in the lateral hip joint that can be severely limiting to activities of daily living, sleep, and overall quality of life. It encompasses numerous disease states causing pain in the region of the greater trochanter of the femur. Non-invasive management approaches of GTPS include corticosteroid injections and physiotherapy, preferred as first-line interventions prior to surgical interventions.
View Article and Find Full Text PDFPublishing Identifiable Patient Photographs in the Digital Age: Focus Group Study of Patients, Doctors, and Medical Students.
J Med Internet Res
March 2025
Department of Research in Biomedicine and Health, Center for Evidence-Based Medicine, University of Split School of Medicine, Split, Croatia.
Background: The publication of patient photographs in scientific journals continues to pose challenges regarding privacy and confidentiality, despite existing ethical guidelines. Recent studies indicate that key stakeholders-including health care professionals and patients-lack sufficient awareness of the ethical considerations surrounding patient photographs, particularly in the context of digital scientific publishing.
Objective: This qualitative study aims to explore how different stakeholders-patients, medical students, and doctors-understand the challenges of patient privacy and confidentiality in scientific publications.
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