recovers disturbance of normal male fertilization in -infected mice.

Schistosomiasis is a parasitic disease and it associated with erectile dysfunction and infertility while possesses anti-oxidant properties. This study evaluates to protect the male fertility, and to preserve sperm quality in ()-infected mice. A 36 male albino mice of six equal sets were used in the study each with 6 mice; Control, cupressuflavone (200 mg/kg), and () (80 mg/kg), infected mice, cupressuflavone (200 mg/kg)   infected mice, and (80 mg/kg)   infected mice for 4 weeks. Serum testosterone, luteinizing hormone, follicle stimulating hormone, dehydroepiandrosterone sulfate, and Sex hormone binding globulin were determined. Glucose-6-phosphate dehydrogenase, 3β-hydroxysteroid dehydrogenase, total protein, and cholesterol in testis were detected. Antioxidants and sodium/potassium-ATPase in the hypothalamus, testis, and sperm were identified. Sperm counts, motility, and abnormality, as well as, sperm monoclonal proliferating antibody Ki-67 were evaluated. The results revealed that decreased superoxide dismutase, glutathione, serum testosterone and dehydroepiandrosterone sulfate, sperm count and motility, sodium/potassium-ATPase activity while increased malondialdehyde, serum follicle stimulating hormone, sex hormone binding globulin, and luteinizing hormone, glucose-6-phosphatedehydrogenase, 3β-hydroxysteroid dehydrogenase, cholesterol, total protein, sperm abnormality, the percentage of spermatogonia, 1st spermatocyte, 2nd spermatocyte, and spermatid in the testis. Also, and cupressuflavone oral administration to -infected group back all of the aforementioned parameters to be close control values where had an efficient impact than cupressuflavone did. In conclusion, sustains testosterone cycle and sperm quality in -related testicular dysfunction.