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| http://dx.doi.org/10.9740/mhc.2025.02.001 | DOI Listing |
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Dopamine receptor D2 (DRD2) TaqIA gene polymorphism and acute risperidone-induced changes in body weight, plasma glucose and lipid profile.
Schizophr Res
March 2025
Department of Psychiatry, University of Botswana, Gaborone, Botswana.
There are indications that the transient blockade of the dopamine receptor D2 (DRD2) by atypical antipsychotics such as risperidone is related to their metabolic side effects. We, therefore, examined the relationship between TaqIA polymorphism of the DRD2 gene and acute risperidone-induced metabolic changes. We recruited 153 newly diagnosed patients with psychotic disorders (71 males and 82 females) from the Federal Neuropsychiatric Hospital, Yaba, Lagos, Nigeria.
View Article and Find Full Text PDFPaliperidone-induced neuroleptic malignant syndrome: A case report.
Medicine (Baltimore)
March 2025
Clinic of Psychiatry, Mersin Sehir Egitim ve Arastirma Hastanesi, Toroslar, Mersin, Turkey.
Rationale: Neuroleptic malignant syndrome (NMS) is a rare, life-threatening complication of neuroleptic (antipsychotic) medications. Paliperidone is an atypical antipsychotic used in the treatment of schizophrenia. While current evidence suggests that atypical oral antipsychotics have a lower incidence of NMS compared to typical oral antipsychotics, there is limited information available on the incidence and management of NMS associated with long-acting injectable (LAI) antipsychotics.
View Article and Find Full Text PDFComparative risk of QTc prolongation induced by second-generation antipsychotics in the real world: retrospective cohort study based on a hospital information system.
BJPsych Open
March 2025
Department of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Background: Second-generation antipsychotics (SGAs) can cause corrected QT interval (QTc) prolongation as a side-effect. This may limit their clinical use and pose safety concerns for patients.
Aims: To analyse the risk of QTc prolongation associated with eight second-generation antipsychotics and observe the timing characteristics of QTc prolongation events and subsequent changes in medication strategies.
Atypical antipsychotics impair the lipid-lowering and pleiotropic effects of simvastatin via activation of the ADMA-NOX-ROS pathway.
Biomed Pharmacother
March 2025
Graduate Institute and Department of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:
Patients with schizophrenia receiving atypical antipsychotics have an increased risk of metabolic syndrome; however, the efficacy of statins in mitigating cardiovascular risks in these patients remains unclear. This study examined the effects of typical and atypical antipsychotics on the lipid-lowering efficacy of statins in schizophrenia patients and investigated the underlying mechanisms of simvastatin action in hepatocytes and endothelial cells (ECs). A retrospective analysis revealed that statins were less effective in lowering LDL levels in patients on atypical antipsychotics.
View Article and Find Full Text PDFHow Early-Life Antipsychotic Drug Administration Modifies Behavioral and Brain Function in Adulthood.
Curr Top Behav Neurosci
March 2025
Department of Psychological Science, Northern Kentucky University, Highland Heights, KY, USA.
The use of antipsychotic drugs in children has greatly expanded over the past 30 years. This increase occurred despite a lack of research addressing how these drugs affect brain development. This review summarizes and synthesizes preclinical studies that have ascertained the short- and long-term consequences of prenatal and early postnatal antipsychotic drug administration.
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