This case study delves into an uncommon occurrence of internal root resorption (IRR), an inflammatory variant with perforation of root, in the left central incisor, which seems to have a prevalence ranging from 0.01% to 1%. The patient presented with pain in the upper left front tooth, leading to a diagnosis of pulpal necrosis with symptomatic apical periodontitis. The initial phase involved identifying the three-dimensional overview of resorption and perforation using cone-beam computed tomography and nonsurgical root canal treatment utilizing orthograde mineral trioxide aggregate (MTA) placement and thermoplasticized obturation technique, aided by sonic-irrigation, and intracanal medicament under magnification. In the later phase, based on the clinical and radiographical evaluation and addressing the complexities of the perforative resorptive lesion, surgical approach needed to be performed. A 6-month follow-up revealed the arrest of IRR and a satisfactory overall outcome. This case report discusses the etiology, prevalence, clinical decision-making, and therapeutic management of IRR.
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http://dx.doi.org/10.4103/JCDE.JCDE_433_24 | DOI Listing |
Epileptic Disord
March 2025
Department of Neurology, Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.
Background: Neuroendocrine carcinomas (NECs) are rare tumors from hormone-secreting neuroendocrine cells, often within the gastrointestinal tract. The authors report what is, to their best knowledge, the first case of a small intestine NEC metastasizing to the temporomandibular joint (TMJ).
Case Description: A 60-year-old man came to the oral medicine, oncology, and orofacial pain clinic with a chief concern of left-sided jaw pain.
Genes Chromosomes Cancer
March 2025
Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Sex cord-stromal tumors are rare in pediatric patients. Leydig cell tumors are a rare subset of sex cord-stromal tumors characterized by unique molecular alterations, including TERT fusions and mutations of CTNNB1, FOXO4, TP53, NBN, MTOR, BAP1, MEN1, and CREBBP. We report a case of a testicular Leydig cell tumor with an EWSR1::CREM fusion, which to our knowledge has not been previously reported in this setting.
View Article and Find Full Text PDFJ Vet Intern Med
March 2025
Animal Endocrine Clinic, New York, New York, USA.
A 9-year-old mixed breed cat with a history of recurrent ulcerated skin lesions was diagnosed with nocardiosis. Three months after initiating potentiated sulfonamide treatment, the cat developed goitrous hypothyroidism, characterized by palpable enlargement of both thyroid lobes, low serum concentrations of total thyroxine (T4) and free thyroxine (fT4), and high serum thyroid-stimulating hormone (TSH) concentration. Thyroid scintigraphy identified symmetrical enlargement of both thyroid lobes, with increased radionuclide (Tc-pertechnetate) uptake.
View Article and Find Full Text PDFMod Rheumatol Case Rep
March 2025
Department of Infection and Immunology, Allergy and Immunology Center, Aichi Children's Health and Medical Center, Aichi, Japan.
Calcinosis is an intractable condition in juvenile dermatomyositis. The effect of abatacept on calcinosis remains controversial. We describe a case of an 8-year-old boy in whom the addition of abatacept to mycophenolate mofetil was effective against calcinosis in juvenile dermatomyositis.
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