Anterior uveitis frequently occurs in ocular cytomegalovirus (CMV) infection among immunocompetent individuals. Here, we report a rare instance of bilateral isolated intermediate uveitis without retinitis or retinal vasculitis in an immunocompetent individual, later confirmed to be an ocular CMV infection. He was treated with systemic ganciclovir and topical corticosteroid. His symptoms and ocular signs have significantly improved. This case highlights the diverse ocular manifestations seen in ocular CMV infection among immunocompetent individuals.
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http://dx.doi.org/10.7759/cureus.77737 | DOI Listing |
Sci Transl Med
March 2025
Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA.
Congenital cytomegalovirus (cCMV) is the leading infectious cause of neonatal neurological impairment worldwide, but the viral factors enabling vertical spread across the placenta remain undetermined. The pentameric complex (PC), composed of the subunits gH/gL/UL128/UL130/UL131A, has been demonstrated to be important for entry into nonfibroblast cells in vitro. These findings link the PC to broad cell tropism and virus dissemination in vivo, denoting all subunits as potential targets for intervention strategies and vaccine development.
View Article and Find Full Text PDFBackground: Kidney transplantation (KT) has dramatically improved the quality of life of patients with end-stage kidney disease. However, the incidence of opportunistic infections has also increased because of immunosuppression. A common infection after KT is cytomegalovirus (CMV).
View Article and Find Full Text PDFEur J Immunol
March 2025
Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Immunosenescence, age-related immune dysregulation, reduces immunity upon vaccinations and infections. Cytomegalovirus (CMV) infection results in declining naïve (T) and increasing terminally differentiated (T) T cell populations, further aggravating immune aging. Both immunosenescence and CMV have been speculated to hamper the formation of protective T-cell immunity against novel or emerging pathogens.
View Article and Find Full Text PDFAm J Hematol
March 2025
Center for Immuno-Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Cytomegalovirus (CMV) infection post-hematopoietic cell transplantation (HCT) remains a significant cause of morbidity and mortality. While letermovir prophylaxis is available for CMV-seropositive recipients, optimal donor selection for CMV-seronegative recipients remains unclear, with donor age often prioritized over CMV serostatus. We investigated the relative impact of donor age and CMV serostatus in CMV-seronegative recipients (n = 1013) with either CMV-seropositive (n = 318) or CMV-seronegative donors (n = 695), who underwent HCT with HLA-matched sibling donors with calcineurin inhibitor-based or post-transplant cyclophosphamide (PTCy)-based graft-versus-host disease prophylaxis, or haploidentical donors with PTCy.
View Article and Find Full Text PDFOpen Forum Infect Dis
December 2024
Department of Obstetrics and Gynaecology, Makerere University College of Health Sciences, Kampala, Uganda.
Background: Maternal primary cytomegalovirus (CMV) infection is associated with abortion and congenital anomalies. In Uganda, the burden of maternal CMV infection is not well studied. This study thus assessed the seroprevalence and factors associated with CMV infection among pregnant women at Kawempe National Referral Hospital in Kampala.
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