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Mirabegron-induced acute urticaria: An uncommon cutaneous adverse drug reaction.
Indian J Pharmacol
November 2024
Department of Dermatology, Venereology, and Leprosy, KPC Medical College and Hospital, Kolkata, West Bengal, India.
MIRABEGRON INDUCED RELAXATION OF ISOLATED BOVINE CORONARY SEGMENTS: ROLE OF NO AND K+ CHANNEL.
Georgian Med News
February 2024
College of Pharmacy, University of Mosul, Iraq.
It was already known that mirabegron, a β3-adrenoceptor agonist, affected cardiac muscle, data also demonstrated that mirabegron induced a relaxant effect in rat aortic vessels by a mechanism dependent on nitric oxide production. This study examined the possible effects of mirabegron on the coronary vascular tone. Results show that mirabegron induced an acute relaxant effect on coronary segments' contractility, and the relaxation is partly dependent on nitric oxide and K+ channel activation.
View Article and Find Full Text PDFHuman β3-Adrenoreceptor is Resistant to Agonist-Induced Desensitization in Renal Epithelial Cells.
Cell Physiol Biochem
September 2018
Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy.
Background/aims: We recently showed that the β3-adrenoreceptor (β3AR) is expressed in mouse kidney collecting ducts (CD) cells along with the type-2 vasopressin receptor (AVPR2). Interestingly, a single injection of a β3AR selective agonist promotes a potent antidiuretic effect in mice. Before considering the feasibility of chronic β3AR agonism to induce antidiuresis in vivo, we aimed to evaluate in vitro the signaling and desensitization profiles of human β3AR.
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