Objective: Non-alcoholic fatty liver disease is a risk factor for atrial fibrillation. We assessed whether liver fibrosis markers are associated with atrial remodeling indicators in patients with atrial fibrillation in whom fatty liver disease has not been identified.
Methods: In this prospective, observational study, 174 patients with atrial fibrillation without chronic liver disease who underwent catheter ablation were enrolled. Using blood collected from the right atrium, type IV collagen (COL4), type IV collagen 7S (COL4-7S), and tumor necrosis factor-α concentrations were measured as markers of liver fibrosis and inflammation. The left atrial volume and P-wave duration were used as atrial remodeling indicators.
Results: Left atrial volume was significantly positively correlated with COL4, COL4-7S, and tumor necrosis factor-α concentrations. COL4-7S concentrations were significantly positively correlated with tumor necrosis factor-α concentrations and the P-wave duration. To exclude the effect of alcohol consumption, a multiple regression analysis was performed for left atrial volume in patients with a <30-g daily alcohol intake (n = 124). Age, sex, and COL4-7S were significant explanatory variables (R = 0.44, adjusted R2 = 0.142, COL4-7S standardized β = 0.20).
Conclusion: Liver fibrosis may be involved in atrial remodeling via inflammation in patients with atrial fibrillation who do not have obvious fatty liver disease.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11840850 | PMC |
| http://dx.doi.org/10.1177/03000605251314832 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Successful Percutaneous Extraction of a WATCHMAN FLX Device From the Left Ventricular Outflow Tract.
JACC Case Rep
January 2025
Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:
Background: Although rare, embolization of left atrial appendage occlusion (LAAO) devices carries a significant morbidity and mortality burden.
Case Summary: An asymptomatic 77-year-old woman with inability to tolerate anticoagulation due to gastrointestinal bleeding presented for 45-day transesophageal echocardiography following LAAO with a Watchman device, which demonstrated incidental device migration to the left ventricular outflow tract (LVOT). Percutaneous extraction was performed using a novel technique with rat tooth/alligator forceps to successfully retrieve the Watchman from the LVOT using a transaortic approach.
Identifying Extra Pulmonary Vein Targets for Persistent Atrial Fibrillation Ablation: Bridging Advanced and Conventional Mapping Techniques.
Europace
March 2025
Cardiology Department, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, United Kingdom.
Background And Aims: Advanced technologies such as charge density mapping (CDM) show promise in guiding adjuvant ablation in patients with persistent atrial fibrillation (AF); however, their limited availability restricts widespread adoption. We sought to determine whether regions of the left atrium containing CDM-identified pivoting and rotational propagation patterns during AF could also be reliably identified using more conventional contact mapping techniques.
Methods: Twenty-two patients undergoing de novo ablation of persistent AF underwent both CDM and electroanatomic voltage mapping during AF and sinus rhythm with multiple pacing protocols.
Cerebral Protection Devices in Case of Left Sided Intracardiac Thrombus: A Multicentre Experience From the Cath Lab and EP Lab.
Catheter Cardiovasc Interv
March 2025
Division of arrhythmology, San Raffaele Hospital, Milan, Italy.
Background: Performing a left atrial appendage occlusion (LAAO) or catheter ablation with left-sided intracardiac thrombus is considered very-high risk for periinterventional stroke. Cerebral embolic protection (CEP) devices are designed to prevent cardioembolic stroke and have been widely studied in TAVR procedures. However, their role in LAAO and catheter ablation of ventricular tachycardia (VT) or in pulmonary vein isolation (PVI) with cardiac thrombus present remains unknown.
View Article and Find Full Text PDFCase Report: Fatal atrioesophageal fistula following atrial fibrillation ablation-critical reflections on prevention.
Front Cardiovasc Med
February 2025
Department of Radiology, Ningbo No.2 Hospital, Ningbo, China.
Radiofrequency ablation (RFA) is an important therapeutic modality for atrial fibrillation (AF), widely utilized in clinical practice due to its safety and significant efficacy. However, post-procedural complications may arise, influenced by anatomical positioning and the intensity of ablation energy, with atrioesophageal fistula (AEF) being particularly rare yet severe. This case report describes a unique instance of a patient developing AEF following AF ablation, accompanied by ischemic stroke and myocardial infarction.
View Article and Find Full Text PDFThymoma-Induced Severe Biventricular Failure without Myasthenia Gravis: Investigating Tachycardia-Induced Cardiomyopathy.
Am J Case Rep
March 2025
Department of Cardiology, St Vincent's Hospital Sydney, Sydney, New South Wales, Australia.
BACKGROUND Cardiomyopathy associated with thymoma is thought to be a cardiac manifestations of myasthenia gravis (MG). However, there are case reports of newly diagnosed thymoma presenting with cardiomyopathy without MG, and the mechanism remains unclear. The purpose of this report is to explore tachycardia-induced cardiomyopathy (TIC) as a potential mechanism for cardiomyopathy in thymoma without features of MG.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!