We design 3D-printed motor-driven active particles and find that their dynamics can be characterized using the model of overdamped chiral active Brownian particles (ABPs), as demonstrated by measured angular statistics and translational mean squared displacements (MSDs). Furthermore, we propose a minimal model that reproduces the double-peak velocity distributions and further predicts a transition from the single-peak to the double-peak displacement distributions in short-time regimes. The model provides a clear physics picture of these phenomena, originating from the competition between the active motion and the translational diffusion. Our experiments confirm such picture. The minimal model enhances our understanding of activity-driven non-Gaussian phenomena. The designed particles could be further applied in the study of collective chiral motions.
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http://dx.doi.org/10.1103/PhysRevE.111.015404 | DOI Listing |
Eur J Phys Rehabil Med
March 2025
Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China -
Background: There is limited research on the Minimal Important Change (MIC) of the Chinese Western Aphasia Battery (WAB). Since an MIC for Chinese WAB has yet to be established, the clinical implications of data using the Chinese WAB remain unclear.
Aim: This study was to establish the MIC of the Aphasia Quotient (AQ) of the Chinese WAB.
Front Bioeng Biotechnol
February 2025
Brain Tumor Center & Neuro-Oncology Unit, Beth Israel Deaconess Medical Center, Boston, MA, United States.
Purpose: Tumor Treating Fields (TTFields) are delivered by transducer arrays applied to scalp or body surface for treatment of multiple malignancies. Dermatologic complications are thought to be related to hydrogel situated between the electrodes and scalp or skin to facilitate electric field penetration. High intensity of TTFields on these surfaces may also be a contributing factor.
View Article and Find Full Text PDFInt J Nanomedicine
March 2025
Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, People's Republic of China.
Objective: Photodynamic therapy (PDT) is a promising strategy with significant clinical application potential for tumor treatment. However, the tumor hypoxia and limited efficacy against tumor metastasis present significant limitations in the clinical application of PDT. To alleviate tumor hypoxia for PDT against tumor growth and metastasis, we developed a self-oxygenated immunoliposome by encapsulating the catalase (CAT) within the liposome cavity and loading the photosensitizer chlorin e6 (Ce6) and immunoadjuvant MPLA in the lipid bilayer of the immunoliposome (CAT@LP-Ce6-A).
View Article and Find Full Text PDFFront Microbiol
February 2025
Department of Pharmacy, Mie University Hospital, Mie, Japan.
Introduction: Isavuconazole, a broad-spectrum triazole approved by the United States Food and Drug Administration (FDA) in 2015, moderately inhibits cytochrome P450 3A4. Although antifungal agents are often used concomitantly with cyclosporine, the effect of switching from voriconazole to isavuconazole on the blood cyclosporine level remains unclear.
Case: A 63-year-old Japanese male was administered oral cyclosporine (10:00 and 21:00) for severe aplastic anemia.
Campbell Syst Rev
March 2025
School of Public Health and Preventive Medicine Monash University Melbourne Victoria Australia.
Adolescence is a vulnerable period for the onset of mental disorders and risk behaviours. Whole-school interventions hold vast potential in improving mental health and preventing risk behaviours in this developmentally-sensitive cohort. Modelled on the World Health Organisation's Health-Promoting Schools Framework, whole-school interventions aspire for change across eight domains: (i) school curriculum, (ii) school social-emotional environment, (iii) school physical environment, (iv) school governance and leadership, (v) school policies and resources, (vi) school and community partnerships, (vii) school health services and (viii) government policies and resources.
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