Seasonal influenza is still a challenge in the United Arab Emirates (UAE). There is consensus that the most effective way to address this problem is through yearly vaccination campaigns. Despite governmental efforts to make the influenza vaccine available, there remains some hesitancy among the population. Previous research has focused on the conspiratorial and disinformation aspects of vaccine hesitancy. In this article, we posit that, apart from those factors, moral psychology considerations also play a role in determining whether people accept the influenza vaccine. University students in the UAE were assessed in their knowledge of how vaccines work. They were also assessed in their level of adherence to utilitarian moral psychology. Results came out showing that while vaccine knowledge plays a role in the decision to receive the seasonal influenza shot, impartial beneficence (as a dimension of utilitarian psychology) plays a greater role. This has implications for moral education, communication and public policy in the UAE, as an introduction to utilitarian principles may serve the purpose of curbing vaccine hesitancy in the nation.
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http://dx.doi.org/10.1186/s40359-025-02456-y | DOI Listing |
Virology
March 2025
Grupo de Investigación en Microbiología y Epidemiología, Facultad de Medicina Veterinaria y de Zootecnia, Universidad Nacional de Colombia, Bogotá, 111321, Colombia. Electronic address:
Influenza A virus (FLUAV) affects a wide range of hosts, including humans and animals, posing a threat to public health. In swine, H3N2 subtype is associated with human-to-swine spillovers of seasonal viruses. In Latin America, the molecular and antigenic characteristics of swine FLUAV H3N2, as well as its phylogenetic origin, are poorly understood.
View Article and Find Full Text PDFJ Immunol
January 2025
Center for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, United States.
Current influenza vaccines are not effective in conferring protection against antigenic variants and pandemics. To improve cross-protection of influenza vaccination, we developed a 5xM2e messenger RNA (mRNA) vaccine encoding the tandem repeat conserved ectodomain (M2e) of ion channel protein M2 derived from human, swine, and avian influenza A viruses. The lipid nanoparticle (LNP)-encapsulated 5xM2e mRNA vaccine was immunogenic, eliciting high levels of M2e-specific IgG antibodies, IFN-γ+ T cells, T follicular helper cells, germinal center phenotypic B cells, and plasma cells.
View Article and Find Full Text PDFJ Immunol
March 2025
Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, United States.
Antigen-experienced memory B-cells (MBC) are endowed with enhanced functional properties compared to naïve B cells and play an important role in the humoral response. However, the epigenetic enzymes and programs that govern their rapid differentiation are incompletely understood. Here, the role of the histone H3 lysine 27 methyltransferase EZH2 in the formation of MBC in response to an influenza infection was determined in Mus musculus.
View Article and Find Full Text PDFEmerg Microbes Infect
March 2025
Hospices Civils de Lyon (HCL), Centre National des virus des infections respiratoires, Institut des Agents Infectieux, Laboratoire de Virologie, Lyon, France.
Background: The epidemiology of respiratory viruses and vaccine effectiveness (VE) in the community is not well described. This study assessed VE against a positive test of influenza (VEf) and SARS-CoV-2 (VECov).
Methods: Data from two large networks of community-based laboratories in France were collected during standard of care in the 2023-2024 epidemic season (n = 511,083 RT-PCR tests).
Infez Med
March 2025
Department of Biomedical and Clinical Sciences, Università degli Studi di Milano, Milan, Italy.
The first highly pathogenic H5N1 emerged in 1959 on a chicken farm in Scotland. The ancestor of the strains presently circulating was isolated in 1996 from a domestic goose in China. Since 1997, more than 900 severe human infections have been reported.
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