Opioid overdose deaths are an evolving public health emergency in the United States. Recent advancements in drug conjugate vaccine design and adjuvantation technologies have re-ignited interest in the potential clinical utility of opioid vaccination. Here we present the concept of fentanyl vaccination as a complementary strategy for opioid overdose prevention with a focus on vaccine safety, efficacy, and considerations for vaccine development and testing in early phase human clinical trials.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11840009PMC
http://dx.doi.org/10.1038/s41541-025-01083-3DOI Listing

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