Opioid overdose deaths are an evolving public health emergency in the United States. Recent advancements in drug conjugate vaccine design and adjuvantation technologies have re-ignited interest in the potential clinical utility of opioid vaccination. Here we present the concept of fentanyl vaccination as a complementary strategy for opioid overdose prevention with a focus on vaccine safety, efficacy, and considerations for vaccine development and testing in early phase human clinical trials.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11840009 | PMC |
http://dx.doi.org/10.1038/s41541-025-01083-3 | DOI Listing |
Drug Alcohol Depend
March 2025
Rocky Mountain Poison & Drug Safety, Denver Health and Hospital Authority, Denver, CO, USA; Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Background And Aims: Deaths from opioid overdose are increasing in the United States (US) and distribution of the opioid antagonist naloxone is one key strategy to reduce mortality. In this cross-sectional survey, we assess the association of high-risk behaviors with possession of naloxone and knowledge of where to find it.
Setting And Participants: 5663 adults entering treatment for opioid use disorder at facilities throughout the US during the calendar year 2022 were surveyed.
Int J Drug Policy
March 2025
University of Washington Medicine, Department of Psychiatry & Behavioral Sciences, Addictions, Drug & Alcohol Institute, Seattle, WA, USA. Electronic address:
Background: The opioid epidemic presses on as a significant public health issue in the U.S., with particularly high overdose death rates in the Southeast.
View Article and Find Full Text PDFAm J Public Health
April 2025
All authors are with the Office of the Chief Medical Examiner, San Francisco, CA. Luke N. Rodda is also with the Department of Laboratory Medicine, University of California, San Francisco.
To identify drug prevalence through the analysis of drug material and paraphernalia (DMP) collected from scenes of fentanyl-involved fatal accidental drug overdoses in San Francisco, California, throughout 2022. We conducted gas chromatography-mass spectrometry testing on 409 items of DMP (e.g.
View Article and Find Full Text PDFBackground: There were 2227 drug-related deaths in Germany in 2023, corresponding to a rise of 12% over the previous year and a doubling over the course of a decade. Approximately 60% of these deaths were related to opioid consumption. In this narrative review, we discuss whether take-home naloxone (THN) might lower the mortality of persons with opioid dependency.
View Article and Find Full Text PDFCan J Public Health
March 2025
Canadian Institute for Substance Use Research, University of Victoria, Victoria, BC, Canada.
Setting: This paper describes the Safer Opioid Supply (SOS) program, a public health intervention in London, Ontario, in response to the toxic unregulated drug supply which is driving the overdose crisis in Canada.
Intervention: The London InterCommunity Health Centre (LIHC) SOS program provides comprehensive harm reduction and primary health care services to individuals at risk of overdose from the toxic drug supply. Clients are prescribed high-dose pharmaceutical opioids as replacement for unregulated toxic substances within a low-barrier primary care clinic, with wraparound interdisciplinary social services, embedded in the Ontario Community Health Centre model of care.
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