5'-nucleotidases are proteins involved in nucleotide metabolism by dephosphorylating nucleotide monophosphates. A group of four related proteins (NT5DC1-4) has been described and an increasing amount of corresponding data has been published over the last years. Here, we review the current scientific literature on NT5DC proteins, present data on the four proteins, and discuss their potential involvement in cancer and other diseases. It seems that these proteins can have a role in various brain-related diseases, and there is a compelling amount of results showing that in particular NT5DC2 can be considered a drug target in cancer. More work is needed to conclude whether these proteins are involved or not in the nucleotide metabolism and thus potentially in purinergic signaling.
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A phenotypic journey into NT5DC proteins in cancer and other diseases.
Exp Cell Res
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Université Claude Bernard Lyon 1, INSERM U-1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France. Electronic address:
5'-nucleotidases are proteins involved in nucleotide metabolism by dephosphorylating nucleotide monophosphates. A group of four related proteins (NT5DC1-4) has been described and an increasing amount of corresponding data has been published over the last years. Here, we review the current scientific literature on NT5DC proteins, present data on the four proteins, and discuss their potential involvement in cancer and other diseases.
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July 2023
Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
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Department of General Surgery, Beijing Key Laboratory of Cancer Invasion and Metastasis Research and National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People's Republic of China.
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Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, China. Electronic address:
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Department of Respiration, The First Hospital of Jilin University, Changchun, 130021, China. Electronic address:
Non-small cell lung cancer (NSCLC) is a leading cause of tumor mortality worldwide. Nevertheless, the molecular mechanisms revealing NSCLC progression are still unclear. 5'-Nucleotidase domain containing 2 (NT5DC2), as a member of the NT5DC family, contains a haloacid dehalogenase motif localized in the N-terminus of these proteins.
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