Objective: To investigate national trends in newborn circumcision complication and secondary procedure rates and whether clinician specialty affects these rates.
Methods: The Merative MarketScan Database was queried for claims from 2010 to 2022. CPT 54150 identified newborn circumcisions; CPT 54162, 54163, 54164, 54300, and 54450 identified secondary procedures; ICD-9 and ICD-10 codes identified complications. Multivariable logistic regression was performed to analyze the association between clinician specialty and circumcision revision or secondary procedure.
Results: A thirty-day complication was coded for 0.96% of newborns. Two- and five-year secondary procedure rates decreased from 2.90% and 3.62% in 2010 to 2.45% in 2020 and 2.89% in 2017, respectively. Compared to newborn circumcisions performed by obstetrician/gynecologists, the odds of secondary procedure within 2 years were lower for those performed by pediatricians (OR 0.73, 95% CI 0.68-0.78, P <.001), pediatric surgeons (0.57 [0.42-0.76], P <.001), advanced practice clinicians (APC) (0.80 [0.65-0.98], P = .03), and other clinicians (0.67 [0.63-0.71], P <.001). Compared to newborn circumcisions performed by obstetricians/gynecologists, the odds of revision within 2 years were lower for those performed by pediatricians (0.46 [0.42-0.51], P <.001), urologists (0.29 [0.19-0.44], P <.001), pediatric urologists (0.38 [0.22-0.66], P = .001), pediatric surgeons (0.60 [0.36-0.98], P = .04), and other clinicians (0.59 [0.52-0.66], P <.001).
Conclusion: Revision rates did not increase over time, and secondary procedure rates slowly declined. Compared to newborn circumcisions performed by obstetrician/gynecologists, the odds of a secondary procedure were either not different or lower for those performed by all other specialties, including APCs, suggesting that newborn circumcision workforce planning should involve training of and collaboration with APCs.
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http://dx.doi.org/10.1016/j.urology.2025.02.017 | DOI Listing |
Cancer Med
March 2025
Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Background: Tumor metastasis is one of the main causes of death in cancer patients; however, the mechanism controlling metastasis is unclear. The posttranscriptional regulation of metastasis-related genes mediated by AT-rich interactive domain-containing protein 4A (Arid4a), an RNA-binding protein (RBP), has not been elucidated.
Methods: Bioinformatic analysis, qRT-PCR, immunohistochemistry, and immunoblotting were employed to determine the expression of Arid4a in breast tumor tissues and its association with the survival of cancer patients.
Knee Surg Sports Traumatol Arthrosc
March 2025
Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK.
Purpose: This systematic review and meta-analysis aimed to establish the relationship between the number of procedures a hospital or surgeon performs with outcomes following revision knee replacement (RevKR).
Methods: MEDLINE and Embase were searched using Ovid silver platter up to December 2024 for randomised controlled trials and cohort studies that reported RevKR volumes, in at least two categories, performed by hospitals and surgeons and their relationship to patient and provider level outcomes. The primary outcome was re-revision rate.
Thorac Cancer
March 2025
Department of Respiratory Medicine and Hematology, Hyogo Medical University, Nishinomiya, Japan.
Background: Bone metastasis (BoM) is common in advanced cancer, but its incidence in pleural mesothelioma (PM) remains unclear. This study aimed to determine the incidence of BoM in PM patients and assess its prognosis and risk factors to clarify its clinical significance.
Methods: A retrospective analysis was conducted on 515 histologically confirmed PM patients enrolled between January 2011 and December 2020.
Circ Heart Fail
March 2025
Department of Medicine, University of Maryland School of Medicine, Baltimore (M.T.G.).
Background: Despite favorable hemodynamic and neurohormonal effects, endothelin receptor antagonists have not improved outcomes in patients with heart failure (HF), possibly because they cause fluid retention.
Methods: In this randomized, double-blind, multicenter trial (SERENADE [Macitentan in Heart Failure With Preserved Ejection Fraction and Pulmonary Vascular Disease]), we evaluated the effects of an endothelin receptor antagonist, macitentan, in patients with HF, left ventricular ejection fraction ≥40%, and pulmonary vascular disease. After a 4-week placebo run-in (to ensure clinical stability), followed by a 5-week single-blind macitentan run-in, patients who did not exhibit fluid retention were randomized to macitentan or placebo.
Nutr Hosp
March 2025
Facultad de Medicina. Universidad de Castilla-La Mancha.
Introduction: currently there are changes in lifestyle that have been modifying the nutritional culture, moving away from the Mediterranean diet (DMed) and acquiring a more sedentary lifestyle, a fact that has contributed to a significant increase in risk factors. (CVRF) such as obesity and type 2 diabetes mellitus (DM2), and consequently to a global increase in metabolic syndrome (MS) and cardiovascular diseases (CVD), which in the 21st century reinforces being the first cause of morbidity and mortality To reduce this pandemic, a multidisciplinary approach is required focused on the application of primary and secondary prevention strategies for modifiable CVRFs, focused on nutritional promotion and education through the promotion of a healthier lifestyle and diet from childhood, as the one that encompasses the MedD. This dietary pattern, together with physical exercise, has been shown to contribute to the primary and secondary prevention of DM2 and coexisting CVRF.
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