Background: Evidence-based guidelines recommend statins as first-line therapy to reduce the risk of cardiovascular events in patients with cardiovascular disease and/or diabetes. The Centers for Medicare and Medicaid Services assess compliance with these guidelines through performance and process quality measures.
Purpose: To describe innovative practices to address statin use care gaps, to identify successes and challenges of a pharmacist-led statin initiative, and share quality improvement opportunities related to statin quality metrics.
Methods: A retrospective review was conducted in 2023 of patients enrolled in Medicare Advantage value-based care contracts in a large health system. The primary outcome measures were the percentage of patients identified with statin care gaps who met the criteria for statin treatment and the percentage of patients who accepted pharmacist-led recommendations to initiate statin therapy. Outcomes were analyzed using descriptive statistics.
Results: Among those with statin care gaps, 42% met criteria for pharmacist-led statin initiation. Of those who met criteria, 22% accepted pharmacist's recommendation to initiate statin therapy.
Conclusions: Pharmacist-led statin initiation is effective; however, systematic barriers remain to improve statin quality performance. These results can help others adopt innovative practices that target statin care gaps and assess opportunities for quality improvement.
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http://dx.doi.org/10.1097/JHQ.0000000000000465 | DOI Listing |
Drug Deliv Transl Res
March 2025
Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia.
Simvastatin is a potent statin with antioxidant and anti-inflammatory characteristics, often used to treat hyperlipidemia and related cardiovascular disorders. Nonetheless, its therapeutic advantages are limited by poor water solubility and substantial degradation by CYP3A4 enzymes. This research aimed to improve simvastatin's physicochemical characteristics and therapeutic effectiveness by developing 3D-dendritic mesoporous silica nanoparticles as nanocarriers.
View Article and Find Full Text PDFJMIR Med Inform
March 2025
Department of Primary Care and Public Health, Imperial College, Reynolds Building, London, W6 8RP, United Kingdom, 44 0207589.
Background: Patient portal use has been associated with improved patient health and improved adherence to medications, including statins. However, there is limited research on the association between patient portal registration and outcomes such as statin prescription refill adherence in the context of the National Health Service of England, where patient portals have been widely available since 2015.
Objective: We aimed to explore statin prescription refill adherence among general practice patients in England.
Medicine (Baltimore)
March 2025
Department of Critical Care Medicine, Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, China.
This study assesses the causal effects of antihypertensive and lipid-lowering drugs on inflammatory cytokines using a Mendelian randomization (MR) approach. We conducted a drug-targeted MR analysis using data from large-scale genome-wide association studies and eQTL datasets. SNPs near drug target genes served as instrumental variables to investigate the impact of antihypertensive (angiotensin-converting enzyme inhibitors [ACEIs], ARBs) and lipid-lowering drugs (HMGCR inhibitors, proprotein convertase subtilisin/Kexin type 9 [PCSK9] inhibitors, Niemann-Pick C1-like 1 inhibitors) on inflammatory cytokines.
View Article and Find Full Text PDFFront Pharmacol
February 2025
Department of Intensive Care Unit, Ningbo No. 2 Hospital, Ningbo, Zhejiang, China.
Background: Existing research suggests that using statins may reduce the incidence of enteritis caused by and improve the prognosis of patients. This study aimed to explore the relation between -induced enteritis (CDE) and statin use.
Methods: Data were collected from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database.
Cureus
February 2025
Department of Biochemistry, Government Medical College Narsampet, Sarwapuram, IND.
Background: Diabetes mellitus (DM) increases the risk of left ventricular dysfunction (LVD), which can progress to heart failure if undetected. Echocardiography, a non-invasive and cost-effective imaging tool, provides real-time assessment of left ventricular (LV) function and enables early detection of myocardial dysfunction using advanced techniques such as tissue Doppler imaging and strain analysis. Diabetic patients are particularly prone to LVD due to chronic hyperglycemia, insulin resistance, and systemic inflammation, leading to myocardial fibrosis, microvascular dysfunction, and oxidative stress.
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