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Semiautomated Production of Cell-Free Biosensors.
ACS Synth Biol
March 2025
Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, United States.
Cell-free synthetic biology biosensors have potential as effective diagnostic technologies for the detection of chemical compounds, such as toxins and human health biomarkers. They have several advantages over conventional laboratory-based diagnostic approaches, including the ability to be assembled, freeze-dried, distributed, and then used at the point of need. This makes them an attractive platform for cheap and rapid chemical detection across the globe.
View Article and Find Full Text PDFExploring the Anion Site Disorder Kinetics in Lithium Argyrodites.
J Am Chem Soc
March 2025
Institute of Inorganic and Analytical Chemistry, University of Münster, Corrensstrasse 28/30, Münster D-48149, Germany.
Lithium argyrodites LiPS ( = Cl, Br, I) are a promising class of solid-state electrolytes with the potential to achieve high conductivities (>10 mS·cm) necessary for use in solid-state batteries. Previous research has shown that structural factors, in particular, site disorder between the sulfide and halide anions, can impact the ionic conductivity of lithium argyrodites. One current hypothesis for this correlation between anion site disorder and ionic transport is a connection to the lithium-ion substructure.
View Article and Find Full Text PDFIntegrating Ambient In-Home Sensor Data and Electronic Health Record Data for the Prediction of Outcomes in Amyotrophic Lateral Sclerosis: Protocol for an Exploratory Feasibility Study.
JMIR Res Protoc
March 2025
Institute for Data Science and Informatics, University of Missouri, Columbia, MO, United States.
Background: Amyotrophic lateral sclerosis (ALS) leads to rapid physiological and functional decline before causing untimely death. Current best-practice approaches to interdisciplinary care are unable to provide adequate monitoring of patients' health. Passive in-home sensor systems enable 24×7 health monitoring.
View Article and Find Full Text PDFUrinary Biomarkers and Attainment of Cefepime Therapeutic Targets in Critically Ill Children.
Pediatr Infect Dis J
March 2025
From the Department of Pediatrics.
Background: Critically ill children are at risk for subtherapeutic antibiotic concentrations. The frequency of target attainment and risk factors for subtherapeutic concentrations of cefepime in children have not been extensively studied.
Methods: We performed an observational study in critically ill children receiving a new prescription of standard dosing of cefepime for suspected sepsis (≥2 systemic inflammatory response syndrome criteria within 48 hours of cefepime start).
Roflumilast for the Treatment of Seborrheic Dermatitis: A Review.
Skin Therapy Lett
March 2025
University of Central Florida/HCA Healthcare Consortium, Tallahassee, FL, USA.
Seborrheic dermatitis (SD) is a chronic inflammatory skin disorder most commonly affecting areas rich in sebaceous glands, such as the scalp, face, axilla, and groin. Several factors can precipitate SD development, such as colonization of Malassezia, sebocyte activity, impaired immunity, and environmental influences. Topical antifungals, corticosteroids, and calcineurin inhibitors are the current mainstay treatment of SD.
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