A rhodium-catalyzed annulation of 2-azirines with enaminones is presented. This protocol affords a convenient approach to the diversity-oriented synthesis of 4-acyl- and 4-formyl pyrroles with good functional group tolerance. The utility of this reaction has been demonstrated by scale-up preparation, late-stage modification of natural molecules, and synthesis of diverse derivatives.
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Organobase-catalyzed efficient synthesis of 4-acyl-5-aryl tri-substituted triazole linked -glycosides as glycohybrids.
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National Engineering Research Center for Carbohydrate Synthesis, Jiangxi Province Key Laboratory of Natural and Biomimetic Drugs Research, College of Chemistry and Materials, Jiangxi Normal University, Nanchang, Jiangxi 330022, China.
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