Objectives: This study aimed to investigate the impact of Twin Block appliances on intracranial pressure (ICP) in adolescents by measuring the optic nerve sheath diameter (ONSD) using ultrasonography.
Methods: We conducted a prospective study involving 20 adolescents (8 girls and 12 boys) with skeletal mandibular retrognathia undergoing treatment with Twin Block appliances. ONSD measurements were taken at six different time points: before appliance placement (T0), 1 min after placement (T1), 10 min after placement (T2), one month after the start of treatment with twin block (T3), immediately after appliance removal (T4), and 10 min after removal (T5). Mean arterial pressure (MAP), heart rate, and peripheral oxygen saturation (SpO2) were also monitored. Statistical analyses were performed using Friedman and Wilcoxon Signed-Rank tests with Bonferroni correction, considering p < 0.05 as statistically significant.
Results: Significant increases in ONSD were observed at T1 and T2 compared to T0 (p < 0.05), with the highest ONSD recorded at T1. No significant changes in ONSD were noted at T3 or T5, indicating that the initial increase in ONSD was temporary. MAP showed a significant decrease at T2, but no significant changes were observed in SpO2 or heart rate across the time points.
Conclusion: This study is the first to report a significant increase in ICP, as indicated by ONSD, in adolescents using Twin Block appliances. The observed rise in ONSD shortly after appliance placement suggests a temporary increase in ICP. These findings highlight the importance of monitoring intracranial pressure during orthodontic treatment, particularly in adolescents.
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http://dx.doi.org/10.1007/s00784-025-06214-7 | DOI Listing |
J Stomatol Oral Maxillofac Surg
March 2025
Department of Orthodontics, The Affiliated Stomatological Hospital Of Nanjing Medical University, PR China; State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases, PR China; Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, PR China. Electronic address:
Introduction: This study aimed to investigate the hard tissue and soft tissue characteristics related to favorable facial attractiveness outcomes of Class II Twin-block treatment to select suitable patients for this therapy.
Material And Methods: A total of 86 skeletal Class II patients who had undergone Twin-block treatment were included in this study. Post-treatment facial attractiveness was assessed by seven orthodontists using visual analog scale (VAS) scores based on 3D photographs.
Int J Pharm
March 2025
Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, University of Texas at Austin, Austin, TX, United States. Electronic address:
Twin-Screw Melt Granulation (TSMG) has emerged as a viable manufacturing process for continuous granulation due to short residence time (<1 min) while maintaining drug crystallinity. However, TSMG relies on heat and shear, making it challenging to process thermolabile drugs like gabapentin (GABA). The absence of a material-sparing model to evaluate TSMG feasibility for such drugs has limited adoption.
View Article and Find Full Text PDFOrthod Craniofac Res
February 2025
Orthodontics Department, Harvard School of Dental Medicine, Boston, Massachusetts, USA.
Recent developments in aligner materials have enabled them to be a feasible choice for children and adolescents. Aligners offer a treatment modality for Class II correction in growing patients claiming to address a mandibular deficiency. This study aimed to assess the effectiveness of functional aligners in skeletal Class II treatment through a systematic review and meta-analysis of the existing literature.
View Article and Find Full Text PDFShanghai Kou Qiang Yi Xue
December 2024
Department of Stomatology, Hubei Hospital of Traditional Chinese Medicine (Affiliated Hospital of Hubei University of Chinese Medicine, Hubei Academy of Traditional Chinese Medicine). Wuhan 430000, China. E-mail:
Purpose: To explore the application value of invisible orthodontic appliance without brackets in the correction of ClassⅡand ClassⅠmalocclusion in adolescents with mandibular recession.
Methods: A retrospective collection of clinical data was conducted on 114 adolescent patients with ClassⅡand ClassⅠmalocclusion of mandibular retrusion admitted to Hubei Hospital of Traditional Chinese Medicine from February 2020 to October 2022. They were divided into two groups based on different orthodontic methods, with 57 cases in each group.
Clin Oral Investig
February 2025
Department of Dentomaxillofacial Radiology, Bolu Abant Izzet Baysal University, Bolu, Turkey.
Objectives: This study aimed to investigate the impact of Twin Block appliances on intracranial pressure (ICP) in adolescents by measuring the optic nerve sheath diameter (ONSD) using ultrasonography.
Methods: We conducted a prospective study involving 20 adolescents (8 girls and 12 boys) with skeletal mandibular retrognathia undergoing treatment with Twin Block appliances. ONSD measurements were taken at six different time points: before appliance placement (T0), 1 min after placement (T1), 10 min after placement (T2), one month after the start of treatment with twin block (T3), immediately after appliance removal (T4), and 10 min after removal (T5).
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