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Strategic advancements in targeting the PI3K/AKT/mTOR pathway for Breast cancer therapy.
Biochem Pharmacol
March 2025
Department of Medical Oncology & Therapeutics Research, Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA 91010, USA. Electronic address:
Breast cancer (BC) is a complex disease that affects millions of women worldwide. Its growing impact calls for advanced treatment strategies to improve patient outcomes. The PI3K/AKT/mTOR pathway is a key focus in BC therapy because it plays a major role in important processes like tumor growth, survival, and resistance to treatment.
View Article and Find Full Text PDFIntegrating animal tracking and trait data to facilitate global ecological discoveries.
J Exp Biol
February 2025
Department of Biology, University of Oxford, Oxford OX1 3RB, UK.
Understanding animal movement is at the core of ecology, evolution and conservation science. Big data approaches for animal tracking have facilitated impactful synthesis research on spatial biology and behavior in ecologically important and human-impacted regions. Similarly, databases of animal traits (e.
View Article and Find Full Text PDFLooking ahead to an exciting year in 2025.
Eur Heart J
February 2025
European Heart House, 2035 Route des Colles, Les Templiers, CS 80179 BIOT, F-06903 Sophia Antipolis, France.
What can we learn from 100,000 freshwater forecasts? A synthesis from the NEON Ecological Forecasting Challenge.
Ecol Appl
January 2025
Department of Biological Sciences, Virginia Tech, Virginia, USA.
Near-term, iterative ecological forecasts can be used to help understand and proactively manage ecosystems. To date, more forecasts have been developed for aquatic ecosystems than other ecosystems worldwide, likely motivated by the pressing need to conserve these essential and threatened ecosystems and increasing the availability of high-frequency data. Forecasters have implemented many different modeling approaches to forecast freshwater variables, which have demonstrated promise at individual sites.
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