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| http://dx.doi.org/10.1002/pro.70058 | DOI Listing |
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Advancing Recombinant Protein Expression in Komagataella phaffii: Opportunities and Challenges.
FEMS Yeast Res
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State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Komagataella phaffii has gained recognition as a versatile platform for recombinant protein production, with applications covering biopharmaceuticals, industrial enzymes, food additives, etc. Its advantages include high-level protein expression, moderate post-translational modifications, high-density cultivation, and cost-effective methanol utilization. Nevertheless, it still faces challenges for the improvement of production efficiency and extension of applicability.
View Article and Find Full Text PDFDeep-Learning-Assisted Understanding of the Self-Assembly of Miktoarm Star Block Copolymers.
ACS Nano
March 2025
School of Chemical Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, China.
The self-assemblies of topological complex block copolymers, especially the AB type miktoarm star ones, are fascinating topics in the soft matter field, which represent typical self-assembly behaviors analogous to those of biological membranes. However, their diverse topological asymmetries and versatile spontaneous curvatures result in rather complex phase separations that deviate significantly from the common mechanisms. Thus, numerous trial-and-error experiments with tremendous parameter space and intricate relationships are needed to study their assemblies.
View Article and Find Full Text PDFIn situ global mapping of protein perturbations via protein abundance and conformation analysis.
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State Key Laboratory of Natural Medicines, China Pharmaceutical University, No. 639 Longmian Dadao, Nanjing, 211198, China. Electronic address:
Background: Traditional studies of protein responses to external stimuli primarily focus on changes in protein abundance, often overlooking the critical role of protein conformational alterations. To address this gap, we developed Protein Abundance and Conformation Analysis (PACA), an integrative method that quantifies both protein abundance and conformational changes. PACA combines conventional quantitative proteomics for abundance measurements with Target Response Accessibility Profiling (TRAP), a technique that captures conformational changes in situ by applying reductive dimethylation to label accessible lysine residues in living cells before lysis.
View Article and Find Full Text PDFMitochondrial genetic markers based phylogenetic analyses of Hyalomma dromedarii Koch, 1844 (Acari: Ixodidae).
J Genet Eng Biotechnol
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Department of Veterinary Parasitology, College of Veterinary Science, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana 125004, India.
The hard tick Hyalomma dromedarii, a vector for numerous animal and human pathogens, was investigated for genetic diversity using the mitochondrial cytochrome C oxidase subunit I (cox I) and 16S ribosomal RNA (16S rRNA) genes. Hyalomma dromedarii sequences (n = 11 cox I; n = 7 16S rRNA) were deposited in GenBank (LC761179-89, LC761173-78, LC654692), showing 99.52-100 % (cox I) and 98.
View Article and Find Full Text PDFThe lateralization of reading.
Handb Clin Neurol
March 2025
Department of Psychology, Center for Visual Cognition, Copenhagen University, Copenhagen, Denmark.
Reports in the 1890s described reading disorders from left hemisphere damage. Subsequent work converging from a variety of research approaches have confirmed a strong dependence of reading on the left ventral occipitotemporal cortex, though there is also evidence for some reading capacity of the right hemisphere. The development of this leftward bias parallels reading acquisition in children and adults and is blunted in developmental dyslexia.
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