Aim: To determine the risk of Grades IV and V kidney injury due to common children's sports.
Methods: A systematic review of studies reporting traumatic kidney injuries (TKIs) associated with basketball, cycling, equestrian, motorsports, netball, rugby, Australian football or soccer. Studies with patients exclusively 18 years or older, non-TKIs or non-sport-related mechanisms were excluded.
Results: Twenty-five studies with 24 424 patients were included. The estimated risk of kidney loss from sports injuries is 0.37 per million child-years. However, the incidence of Grades IV and V injuries could not be calculated in at-risk populations due to limited prospective data. The prevalence of TKIs from sport-specific trauma was low, ranging from 0.6% to 2.2%. Few studies graded the severity of kidney injury, but in the small number reported, Grades IV and V injuries occurred in 33% of soccer TKIs, 26% of bicycling, 23% of Australian football, 20% of basketball and 17% of equestrian injuries. The high number of ungraded kidney injuries (5514/5607) impacts the reliability of findings.
Conclusion: Recommendations to exclude children with congenital single kidneys from specific sports lack a firm evidence-base. Given bio-psycho-social consequences, such recommendations must be carefully considered, particularly for equestrian and motorised vehicles, which carry a higher risk of trauma.
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http://dx.doi.org/10.1111/apa.70014 | DOI Listing |
Acute Crit Care
February 2025
Department of Nephrology, Pusan National University School of Medicine, Yangsan, Korea.
The 2012 Kidney Disease Improving Global Outcomes guidelines clearly define emergent indications for kidney replacement therapy; however, whether dialysis should be initiated in critically ill patients without these indications remains unclear. This review briefly summarizes the results of recent landmark trials and discusses their limitations originating from a criteria-based approach at a single time point. Moreover, a personalized approach based on each patient's demand-capacity balance and its future benefits as a platform for kidney support therapy in critically ill patients are discussed.
View Article and Find Full Text PDFZhong Nan Da Xue Xue Bao Yi Xue Ban
October 2024
Research for Genetic Epidemiology and Genomics, School of Public Health, Suzhou Medical College of Soochow University, Suzhou Jiangsu 215123, China.
Objectives: Osteoporosis is characterized by decreased bone mass and damaged bone microstructure, often leading to fragility fractures. Low bone mineral density is a key risk factor for fractures. Serum cystatin C (CysC), an endogenous marker of glomerular filtration rate, is negatively correlated with bone mineral density and may be a potential risk factor for osteoporosis.
View Article and Find Full Text PDFCell Signal
March 2025
Traditional Chinese Medicine Integrated Department of Nephrology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, PR China; Research Institute of Nephrology, Zhengzhou University, Zhengzhou 450052, PR China; Henan Province Research Center for Kidney Disease, Zhengzhou 450052, PR China; Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou 450052, PR China; Tianjian Laboratory of Advanced Biomedical Sciences, Academy of Medical Sciences, Zhengzhou University Zhengzhou, Henan, China; Innovation Center of Basic Research for Metabolic-Associated Fatty Liver Disease, Ministry of Education of, China. Electronic address:
Acute kidney injury (AKI) lacks a definitive therapeutic approach beyond supportive care. One significant pathological mechanism involves the regulated death of tubular epithelial cells; however, the regulatory mechanisms underlying this cell death pathway require further investigation. The N6-methyladenosine (m6A) modification, recognized as the most prevalent modification in eukaryotes, plays a critical role in the regulatory processes associated with AKI.
View Article and Find Full Text PDFCan J Cardiol
March 2025
Department of Cardiology, Rabin Medical Center, Petah Tikva, Israel; The Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Background: The use of transcatheter aortic valve implantation (TAVI) for severe aortic stenosis is expanding to patients across the entire spectrum of surgical risk. We aimed to perform a meta-analysis comparing TAVI and surgical aortic valve replacement (SAVR) in trials enrolling lower risk patients.
Methods: We conducted a meta-analysis of randomized controlled trials (RCTs) comparing safety and efficacy outcomes between TAVI and SAVR among lower risk patients (mean/median STS score <4).
Fortschr Neurol Psychiatr
March 2025
Vinzenz von Paul Hospital gGmbH, Rottweil, Germany.
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