Nosocomial ventriculitis can be an extremely difficult infectious disease process to diagnose, thereby exposing patients to increased morbidity and unwarranted aggressive antibiotics. Thus, novel ventriculitis diagnostics are drastically needed. In this study, we demonstrate excellent sensitivity and specificity of cerebral spinal fluid α-defensins to aid in diagnosing ventriculitis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834977 | PMC |
| http://dx.doi.org/10.1093/ofid/ofaf060 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Performance of α-Defensins in Diagnosing Nosocomial Ventriculitis.
Open Forum Infect Dis
February 2025
The Doub Laboratory of Translational Bacterial Research, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Nosocomial ventriculitis can be an extremely difficult infectious disease process to diagnose, thereby exposing patients to increased morbidity and unwarranted aggressive antibiotics. Thus, novel ventriculitis diagnostics are drastically needed. In this study, we demonstrate excellent sensitivity and specificity of cerebral spinal fluid α-defensins to aid in diagnosing ventriculitis.
View Article and Find Full Text PDFRevealing the diagnostic value of cerebrospinal fluid presepsin (sCD14) as a new biomarker for postneurosurgical and nosocomial central nervous system infections: A systematic review and meta-analysis of diagnostic test accuracy studies.
Clin Neurol Neurosurg
February 2025
Faculty of Medicine, Al-Azhar University, Cairo, Egypt; Medical Research Group of Egypt, Negida Academy, Arlington, MA, USA. Electronic address:
Background: Central nervous system (CNS) infections represent life-threatening conditions. Emerging evidence suggests cerebrospinal fluid (CSF) presepsin (sCD14) as a promising biomarker for these infections. However, its diagnostic accuracy remains controversial.
View Article and Find Full Text PDFTreatment Options for Nosocomial Ventriculitis/Meningitis: A Case Report and Review of the Literature.
Pathogens
December 2024
Intensive Care Unit, Department of Anesthesiology and Critical Care, AHEPA University Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Ventriculo-meningitis or nosocomial meningitis/ventriculitis is a severe nosocomial infection that is associated with devastating neurological sequelae. The cerebrospinal fluid isolates associated with the infection can be Gram-positive or -negative, while the spp. is rarely identified.
View Article and Find Full Text PDFCerebrospinal fluid proteomics reveals the innate immunity and blood-brain barrier dysregulation in a patient with multidrug-resistant ventriculitis treated with intrathecal and intravenous polymyxin B.
Heliyon
December 2024
Department of Critical Care Medicine, The Second Clinical Medical College, Jinan University (Shenzhen People's Hospital), Shenzhen, 518020, China.
is a major pathogen of nosocomial meningitis and ventriculitis. Due to very limited antibiotic treatment options, polymyxins are often used as a last-line therapy. To optimise polymyxin use in the intraventricular environment, cerebrospinal fluid (CSF) proteomics was employed to investigate host-pathogen-polymyxin interactions in a 69-year-old patient with multidrug-resistant ventriculitis treated with a combination of intrathecal (ITH; 50,000 IU q24h/q48h), intraventricular (IVT; 50,000 IU q48h), and intravenous (500,000 IU, q12h) polymyxin B.
View Article and Find Full Text PDFCerebrospinal Drain Infection by : A Case Report and Review of the Literature.
J Fungi (Basel)
December 2024
First Department of Critical Care Medicine, Evangelismos Hospital, Medical School, National and Kapodistrian University of Athens, 106 76 Athens, Greece.
is notorious for its ability to spread within healthcare environments, particularly in intensive care units (ICUs), posing significant challenges for clinicians as treatment options become limited. This is especially concerning in the context of central nervous system (CNS)-invasive infections. While rare, its involvement in nosocomial brain ventriculitis presents substantial diagnostic and therapeutic challenges, with no established guidelines for managing CNS infections caused by .
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!