Pancreatitis, panniculitis, and polyarthritis (PPP) syndrome is a rare manifestation (prevalence 2%-3%) of underlying pancreatic pathology which is characterized by fat necrosis in subcutaneous tissue and joints. The widely accepted etiological hypothesis is systemic dissemination of pancreatic lipase. It has a mortality rate approaching 25%. We present a case of pancreatitis, panniculitis, and polyarthritis syndrome in a 52-year-old man with chronic pancreatitis complicated by pancreatico-pericardial fistula.
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http://dx.doi.org/10.14309/crj.0000000000001601 | DOI Listing |
Rheumatol Int
March 2025
Department of Rheumatology and Connective Tissue Diseases, Medical University, St. Jaczewskiego 8, 20-090, Lublin, Poland.
Pancreatic panniculitis (PP) and arthritis may be extrapancreatic manifestations of pancreatic disease. The triad of pancreatic disease, panniculitis and polyarthritis, described in the literature as the PPP syndrome, is sometimes observed in patients with acute or chronic pancreatitis, pancreatic cancer or neuroendocrine tumors (NETs). We present a 60-year-old man with polyarthritis and clinically aggressive PP of the limbs.
View Article and Find Full Text PDFCureus
January 2025
Department of Dermatology, Lewis Katz School of Medicine at Temple University, Philadelphia, USA.
Pancreatic panniculitis (PP) is a rare cutaneous manifestation of pancreatic disease, often presenting as tender, erythematous, subcutaneous nodules, typically on the lower extremities. It can also affect the upper extremities, buttocks, and abdomen. PP is associated with conditions such as acute pancreatitis, pancreatic acinar cell carcinoma, and pancreatic adenocarcinoma.
View Article and Find Full Text PDFACG Case Rep J
February 2025
Department of Medical Gastroenterology, Sawai Man Singh Medical College and Hospital, Jaipur, India.
Pancreatitis, panniculitis, and polyarthritis (PPP) syndrome is a rare manifestation (prevalence 2%-3%) of underlying pancreatic pathology which is characterized by fat necrosis in subcutaneous tissue and joints. The widely accepted etiological hypothesis is systemic dissemination of pancreatic lipase. It has a mortality rate approaching 25%.
View Article and Find Full Text PDFRheumatology (Oxford)
February 2025
Rheumatology and Autoinflammatory diseases, IRCCS Istituto Giannina Gaslini, Genova, Italy.
Objectives: To confirm the presence of different disease phenotypes of pediatric SAPHO syndrome (pSAPHO) based on their skin manifestations in a large cohort of Italian patients.
Methods: pSAPHO were enrolled in the Eurofever Registry and the data retrospectively analysed. Patients were divided depending on their skin manifestations into an Acne-Hidradenitis suppurativa (HS) group and a Palmoplantar Pustulosis-Psoriasis Vulgaris (PPP-PV) group and were compared with patients without skin manifestations (chronic non-bacterial osteomyelitis, CNO).
BMC Biol
February 2025
Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, China.
Background: Lung ischemia-reperfusion (I/R) injury is a common clinical pathology associated with high mortality. The pathophysiology of lung I/R injury involves ferroptosis and elevated protein O-GlcNAcylation levels, while the effect of O-GlcNAcylation on lung I/R injury remains unclear. This research aimed to explore the effect of O-GlcNAcylation on reducing ferroptosis in pulmonary epithelial cells caused by I/R.
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