Cavernous malformations (CMs), also known as cavernomas or cavernous hemangiomas, are vascular lesions characterized by clusters of abnormally dilated blood vessels resembling a mulberry. In this report, we present the case of a 40-year-old man who presented with a one-year history of back pain radiating into both legs, with a preference for the left leg. An MRI initially suggested a schwannoma at the T12-L1 vertebral level, with a differential diagnosis that included meningioma-2 common intradural-extramedullary spinal tumors- with distinct management and prognostic implications. However, despite imaging findings consistent with a schwannoma, the final pathology revealed an intradural extramedullary (IDEM) cavernous hemangioma in the thoracolumbar region. Although cavernous hemangiomas are very rare in the spinal region, our case underscores the importance of considering them in the differential diagnosis of IDEMs in the thoracolumbar area.
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http://dx.doi.org/10.1016/j.radcr.2025.01.043 | DOI Listing |
Indian J Otolaryngol Head Neck Surg
January 2025
Department of ENT, Shaikh Zayed Hospital, Shaikh Zayed Medical Complex, Lahore, Pakistan.
Unlabelled: Cavernous hemangiomas are venous malformations characterized by interconnected channels of abnormally dilated blood vessels having low flow of blood. Whilst venous malformations most commonly affect the head and neck region, isolated cavernous hemangiomas of the palatine tonsils are extremely rare; with only 4 cases being reported in the English Literature. We report a case of a 43-year-old female who was referred to us for the evaluation and management of a right tonsillar swelling.
View Article and Find Full Text PDFOphthalmol Retina
March 2025
Department of Ophthalmology, University of Paris Cité, Lariboisière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
Surg Neurol Int
February 2025
Department of Surgery, University of Baghdad, College of Medicine, Baghdad, Iraq.
Background: With its vital ocular and adnexal structures, the orbit may be affected by a wide array of neoplasms, including primary, secondary, and metastatic neoplasms. These lesions pose significant diagnostic and therapeutic challenges in view of complex orbital anatomy and overlapping clinical presentations. This study aimed to analyze the epidemiology, clinical features, refractive impacts, and management outcomes of orbital tumors, providing insights to optimize diagnosis and treatment strategies.
View Article and Find Full Text PDFElife
February 2025
Department of Medicine, University of California, San Diego, San Diego, United States.
Previously, we showed that propranolol reduces experimental murine cerebral cavernous malformations (CCMs) and prevents embryonic caudal venous plexus (CVP) lesions in zebrafish that follow mosaic inactivation of (Li et al., 2021). Because morpholino silencing of the β1 adrenergic receptor () prevents the embryonic CVP lesion, we proposed that plays a role in CCM pathogenesis.
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