The chemical process industry (CPI) faces significant challenges in improving sustainability and efficiency while maintaining conservative principles for managing cost, complexity, and uncertainty. This work introduces a data-driven approach to dynamic real-time optimization (D-RTO) that addresses the aforementioned concerns by directly extracting process optimization policies from historical plant data. Our method constructs a value function to evaluate trajectory quality and employs weighted regression to derive improved policies. When applied to a plant-wide industrial process control problem, the proposed optimizer demonstrates superior performance in adapting to disturbances while maintaining stability and product quality. These results challenge conventional assumptions regarding the potential of data-driven optimization in the CPI. Although limitations exist due to the black-box nature of neural networks, this study presents a promising avenue for enhancing operational efficiency in industrial settings. The proposed approach offers a practical solution for process optimization, as it leverages readily available historical data and does not require extensive modeling efforts. By demonstrating significant efficiency improvement on a realistic industrial benchmark problem, this work paves the way for the adoption of data-driven optimization techniques in real-world CPI applications.
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http://dx.doi.org/10.1038/s44172-025-00368-8 | DOI Listing |
JMIR Med Inform
March 2025
Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo, Chiba, 260-8677, Japan, 81 432262372.
This study demonstrated that while GPT-4 Turbo had superior specificity when compared to GPT-3.5 Turbo (0.98 vs 0.
View Article and Find Full Text PDFJ Am Chem Soc
March 2025
Department of Chemistry, University of California, Berkeley, Berkeley, California 94720, United States.
Metal halide perovskites have excellent optoelectronic properties. This study aims to determine how the optoelectronic properties of a model perovskite, cesium lead bromide (CsPbBr), change with length and thickness in one dimension (1D). By examining the photophysics of CsPbBr quantum dots (QDs), nanowires (NWs), and nanorods (NRs), we observe the influence of confinement, exciton diffusion, and trapping on their optical properties.
View Article and Find Full Text PDFSci Transl Med
March 2025
Lundquist Institute, Harbor-University of California at Los Angeles (UCLA) Medical Center, Torrance, CA 90502, USA.
Mucormycosis is a fungal infection caused by Mucorales fungi that cause severe disease and fatality, especially in immunocompromised individuals. Although vaccines and immunotherapeutics have been successful in combating viral and bacterial infections, approved antifungal immunotherapies are yet to be realized. To address this gap, monoclonal antibodies targeting invasive fungal infections have emerged as a promising approach, particularly for immunocompromised patients who are unlikely to maximally benefit from vaccines.
View Article and Find Full Text PDFGigascience
January 2025
Concordia University, Department of Computer Science and Software Engineering, 1455 Blvd. De Maisonneuve Ouest, Montreal, Quebec H3G 1M8, Canada.
Magnetic resonance imaging (MRI) preprocessing is a critical step for neuroimaging analysis. However, the computational cost of MRI preprocessing pipelines is a major bottleneck for large cohort studies and some clinical applications. While high-performance computing and, more recently, deep learning have been adopted to accelerate the computations, these techniques require costly hardware and are not accessible to all researchers.
View Article and Find Full Text PDFJMIR Form Res
March 2025
McLean Hospital, Harvard Medical School, 115 Mill Street, South Belknap, Belmont, US.
Background: Phenylketonuria (PKU) is a rare, hereditary disease that causes disruption in phenylalanine (Phe) metabolism. Despite early intervention, individuals with PKU may have difficulty in several different cognitive domains, including verbal fluency, processing speed, and executive functioning.
Objective: The overarching goal of the Evaluating Fluctuations in Cognitive and Speech Characteristics in Phenylketonuria study (CSP Study) is to characterize the relationships among cognition, speech, mood, and blood-based biomarkers (Phe, Tyr) in individuals with early treated PKU.
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