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Current Medical Therapy for Adenomyosis: From Bench to Bedside.
Drugs
November 2023
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, Italy.
Adenomyosis, characterized by the growth of endometrial tissue within the uterine wall, poses significant challenges in treatment. The literature primarily focuses on managing abnormal uterine bleeding (AUB) and dysmenorrhea, the main symptoms of adenomyosis. Nonsteroidal anti-inflammatory drugs (NSAIDs) and tranexamic acid provide limited support for mild symptoms or symptom re-exacerbation during hormone therapy.
View Article and Find Full Text PDFMedical treatment of uterine arteriovenous malformation: a systematic review and meta-analysis.
Fertil Steril
October 2021
Department of Obstetrics and Gynaecology, University of Toronto, Mount Sinai Hospital, Toronto, Ontario, Canada. Electronic address:
Objective: To quantify the efficacy of medical management of uterine arteriovenous malformation (AVM) and compare efficacy between different classes of medication. In addition, we evaluated for factors associated with treatment success and pregnancy outcomes after medical management.
Design: Systematic review and meta-analysis.
Selective androgen receptor modulators (SARMs) have specific impacts on the mouse uterus.
J Endocrinol
September 2019
Centre for Inflammation Research, The University of Edinburgh, Queen's Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK.
Selective androgen receptor modulators (SARMs) have been proposed as therapeutics for women suffering from breast cancer, muscle wasting or urinary incontinence. The androgen receptor (AR) is expressed in the uterus but the impact of SARMs on the function of this organ is unknown. We used a mouse model to compare the impact of SARMs (GTx-007/Andarine®, GTx-024/Enobosarm®), Danazol (a synthetic androstane steroid) and dihydrotestosterone (DHT) on tissue architecture, cell proliferation and gene expression.
View Article and Find Full Text PDFCurcumin attenuates proangiogenic and proinflammatory factors in human eutopic endometrial stromal cells through the NF-κB signaling pathway.
J Cell Physiol
May 2019
Department of Obstetrics and Gynecology, Morehouse School of Medicine, Atlanta, Georgia.
Endometriosis is a chronic gynecological inflammatory disorder in which immune system dysregulation is thought to play a role in its initiation and progression. Due to altered sex steroid receptor concentrations and other signaling defects, eutopic endometriotic tissues have an attenuated response to progesterone. This progesterone-resistance contributes to lesion survival, proliferation, pain, and infertility.
View Article and Find Full Text PDFEffect of laparoscopy combined with mifepristone in the treatment of endometriosis and drug reaction analysis.
Pak J Pharm Sci
May 2018
Obstetrics Department, Yidu Central Hospital of Weifang, Qingzhou, Shandong, China.
Endometriosis is a common benign disease of Gynecology, which often causes symptoms of dysmenorrhea, pelvic pain and infertility. In this paper, we analyzed the effect of laparoscopy combined with mifepristone in the treatment of endometriosis. By observing the clinical efficacy and side effects of small dose mifepristone, we explored the feasibility of small dose mifepristone in the treatment of recurrent endometriosis.
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