The fertility of 742 men visiting our male infertility clinic was studied. A comparison was made between patients operated on for varicocele and patients treated in other ways. Of the men with a varicocele, 37.8% impregnated their partners; of the men without a varicocele, 21.5%. By subdivision of the total group of patients into those with sperm counts above and those with sperm counts below 20 X 10(6)/ml, it appeared that only men with low sperm counts operated on for varicocele showed a significantly higher fertility, as compared with patients not having a varicocele. It is suggested that patients not having oligozoospermia perhaps have spermatozoal defects other than too low a number as the principal cause of their infertility which do not significantly improve after varicocele operation.
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http://dx.doi.org/10.1016/s0015-0282(16)48619-x | DOI Listing |
Arab J Urol
September 2024
Department of Urology, Hamad Medical Corporation, Doha, Qatar.
Objective: To evaluate the effects of age on semen and hormonal parameters following microsurgical varicocelectomy among patients with grade 3 varicocele, and to compare fertility outcomes between younger (<40 years) and older (≥40 years) men.
Methods: Retrospective cohort study of infertile patients with clinical left grade 3 varicocele who underwent microsurgical subinguinal varicocelectomy (MV). Patients meeting the inclusion criteria ( = 550) were divided into two groups based on their age at the time of MV: <40 ( = 441) and ≥40 years ( = 109).
Medicina (Kaunas)
December 2024
Laboratory of Spermatology, Department of Urology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.
Varicocele repair in men with non-obstructive azoospermia (NOA) remains a subject of debate due to inconsistent outcomes. This study aimed to evaluate the impact of microsurgical varicocelectomy on sperm recovery rates in men with NOA and to assess the role of varicocele grade and testicular histopathology in predicting postoperative outcomes. A retrospective cohort study was conducted of 78 men diagnosed with NOA and clinical varicocele who underwent microsurgical subinguinal varicocelectomy with simultaneous diagnostic and therapeutic testicular biopsy at the Department of Urology of the University of Ioannina between September 2013 and December 2021.
View Article and Find Full Text PDFJ Clin Med
December 2024
Third Department of Urology, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece.
Varicoceles are a common contributor to male infertility, significantly impacting male-factor infertility cases. Traditional diagnostic methods often lack the sensitivity to detect the molecular and cellular disruptions caused by varicoceles, limiting the development of effective, personalized treatments. This narrative review aims to explore the advancements in proteomics and metabolomics as innovative, non-invasive diagnostic tools for varicocele-associated male infertility and their potential in guiding personalized therapeutic strategies.
View Article and Find Full Text PDFJ Vasc Interv Radiol
December 2024
Department of Medical Imaging, Western University, London, Ontario, Canada.
The DNA Fragmentation Index (DFI) is a newer and potentially more reliable marker for male infertility, with higher values indicating poorer sperm genetic quality. This study assesses the effect of varicocele embolization on DFI in infertile men. Conducted at a single center from January 2016 to September 2021, this retrospective study involved 22 patients with a mean age of 35.
View Article and Find Full Text PDFHum Reprod Update
December 2024
Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.
Background: Varicocele is an abnormal dilation and torsion of the pampiniform venous plexus in the scrotum due to venous reflux, primarily affecting the left side. It affects 15% of men and is a prevalent contributor to male infertility. Varicocele is a complex disorder influenced by genetic, epigenetic, and environmental factors.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!