A 71-year-old Australian-born man with previous extended travel to the Philippines presented with bilateral lymphoedema, fevers and rigors. Examination of a nocturnal blood film revealed microfilariae of , confirming a diagnosis of Bancroftian filariasis. This case highlights the challenges of diagnosing and managing lymphatic filariasis in non-endemic regions.
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http://dx.doi.org/10.33321/cdi.2025.49.014 | DOI Listing |
Front Public Health
March 2025
Department of Nursing, College of Health Science, Mattu University, Mattu, Ethiopia.
Background: Podoconiosis is non-filarial lymphoedema of the lower extremities. It impairs individuals' overall lives, including their health, economy, psychology, and social interactions. Podoconiosis is a preventable and effectively manageable disease.
View Article and Find Full Text PDFPLoS Negl Trop Dis
March 2025
Department of Pathology, Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, United States of America.
Background: Persons with lymphatic filariasis (LF) are often co-infected with soil-transmitted helminths. A single co-administered dose of ivermectin/diethylcarbamazine/albendazole (IDA) is recommended by WHO for mass drug administration (MDA) for LF instead of diethylcarbamazine/albendazole (DA) in Papua New Guinea (PNG). We compared the effectiveness of a single round of MDA with IDA or DA on hookworm and strongyloidiasis in PNG.
View Article and Find Full Text PDFInt J Infect Dis
March 2025
International Society for Infectious Diseases; S.H. Ho Research Centre for Infectious Diseases, The Chinese University of Hong Kong, Shatin, Hong Kong.
After detection of 2 clinical lymphatic filariasis (LF) cases in a postelimination context in 2023 on the island of Futuna (Wallis and Futuna archipelago), the Wallis and Futuna Health Agency conducted a LF prevalence survey in Futuna in May 2024. This cross-sectional study, carried out among schoolchildren <18 years of age, identified 5 children with antigenemia, indicating an estimated antigenemia prevalence in Futuna children nearing 2%. The study also confirmed a spatial cluster of cases in the village of Taoa, where the child antigenemia prevalence reached 7.
View Article and Find Full Text PDFInt J Biol Macromol
February 2025
Protein Structure-Function and Research Unit, School of Molecular and Cell Biology, Faculty of Science, University of the Witwatersrand, Braamfontein, Johannesburg, 2050, South Africa. Electronic address:
Wuchereria bancrofti glutathione transferase (WbGST) is a therapeutic target in the parasitic worms that cause lymphatic filariasis. We described the molecular and structural basis of WbGST inhibition by Bromosulphophthalein (BSP) and compared it with human Mu (hGSTMu) and Pi (hGSTPi) class GSTs. BSP inhibited WbGST activity with an IC of 5 μM, 13.
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