In this study, adding mulberry leaf flavonoids (MLFs) during the liquid-state fermentation of Monascus purpureus significantly improved the production of Monascus pigments (MPs). Compared with the control group, the red, yellow, and orange pigment levels increased by 1.69, 1.4, and 1.29 times, respectively. Metabolomic analysis suggested adding rutin, the primary component of MLFs, induced changes in 32 significantly different metabolites. These changes included a significant increase in (S)-2,3,4,5-tetrahydropyridine-2-carboxylate, D-4'-phosphopantothenate, cis-4-hydroxy-D-proline, and L-isoleucine. Enriched Kyoto Encyclopedia of Genes and Genomics (KEGG) metabolic pathways revealed valine, leucine, and isoleucine biosynthesis, and phenylalanine metabolism improvements. These improvements help to activate the pigment synthesis pathway and promote pigment synthesis. These findings offer crucial insights into the impact of MLFs on Monascus purpureus metabolic pathways and suggest potential methods for increasing MP production.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12010-025-05183-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mulberry leaf extract combined with tryptophan improves sleep and post wake mood in adults with sleep complaints - A randomized cross-over study.
Eur J Nutr
March 2025
Nestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland.
Purpose: In the current study we evaluated a blend of ingredients containing mulberry leaf extract (to lower postprandial glucose of the evening meal), tryptophan (facilitator of the sleep initiation) to benefit sleep initiation and quality in adults with self-reported difficulties with sleep initiation.
Methods: Forty-three adults aged between 25 and 50 years enrolled in a randomized, crossover, double-blind, controlled trial. Participants received standardized meals with a glycemic load of 55 ± 10% and were assigned to receive treatment comprising a combination of mulberry leaf extract (750 mg), whey protein containing 120 mg tryptophan, zinc (1.
Unraveling molecular mechanisms of 1-deoxynojirimycin and polyphenol biosynthesis in mulberry leaves in response to ultrasound elicitation: An integrated metabolomics and transcriptomics approach.
Food Res Int
April 2025
School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, Jingkou District, Zhenjiang, Jiangsu 212013, PR China; Institute of Food Physical Processing, Jiangsu University, 301 Xuefu Road, Jingkou District, Zhenjiang, Jiangsu 212013, PR China; International Joint Research Laboratory of Intelligent Agriculture and Agri-products Processing, Jiangsu University, Zhenjiang 212013, PR China. Electronic address:
1-Deoxynojirimycin (1-DNJ) and polyphenols are the primary anti-diabetic components in mulberry leaves (MLs) but their low natural abundance limits their application. To address this, we investigated the impact of ultrasonication (US) on the accumulation of 1-DNJ, total phenolic content (TPC), and total flavonoid content (TFC) in MLs. Under the optimal conditions determined by the Box-Behnken design, 1-DNJ, TPC, and TFC levels increased by 2.
View Article and Find Full Text PDFMorus alba L. alleviates influenza viral pneumonia. Evidences of its mechanism of action.
Phytomedicine
February 2025
School of Basic Medicine and Forensics, Hangzhou Medical College, Hangzhou, China; Key Discipline of Zhejiang Province in Public Health and Preventive Medicine (First Class, Category A), Hangzhou Medical College, China. Electronic address:
Background: Viral pneumonia is an infection of the lungs caused by numerous different viruses, which can lead to severe respiratory distress and even life-threatening conditions. In the absence of specific treatments for viral pneumonia, natural traditional medicines offer an alternative in terms of innovative drug therapies. Morus alba L.
View Article and Find Full Text PDFMulberry leaves supplementation modulates ruminal and fecal bacterial community and metabolites in growing mutton sheep.
Sci Rep
March 2025
College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, Shaanxi, China.
Mulberry leaves, a traditional Chinese medicine with the values of medicine and food, are rich in various active ingredients and nutrients. Gastrointestinal bacteria are recognized to play a crucial role in food digestion, nutrient metabolism and the host immune health. However, the modulations of mulberry leaves on microbiota and metabolites remain insufficiently understood.
View Article and Find Full Text PDFIdentification and function analysis of two new gustatory receptors related to silkworm monophagy.
Insect Sci
March 2025
Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, 510631, China.
Silkworm is a typical monophagous insect that can only feed on fresh mulberry leaves. The mechanism for this monophagous nature is not fully understood. One bitter gustatory receptor (GR) GR66 located on the maxilla of the mouthpart has been reported to be an important factor influencing the feeding preference of silkworm.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!