Introduction: Burn injuries are the fifth most common cause of non-fatal injuries among children worldwide. Pediatric burn patients require complex management due to their distinct physiology compared to adults. The purpose of this study is to investigate demographic and clinical factors contributing to a prolonged total hospital duration among pediatric burn patients in a rural, Level 2 Trauma Center and Burn Intensive Care Unit (BICU) located in the Appalachian region.
Methods: Data were collected from 2017 to 2023 and included all patients 18 years and younger who were admitted to the Cabell Huntington Hospital BICU. Patient demographics were analyzed using descriptive statistics. One-way ANOVA assessed the differences between gender and length of stay (LOS) and source of burn and LOS. A chi-square test analyzed the effect of an inhalation injury on LOS. Pearson correlation was used to assess the relationship between BMI and LOS and between total ventilation days (TVD) and LOS.
Results: A total of 232 patients were included in this study, consisting of 102 (44%) females and 130 (56%) males. The average patient age was 6.9 years (SD ± 6.2). The mean LOS was 3.1 (SD ± 4.4) among this cohort. The most common sources of burn injuries within this cohort were flame (43%), scald (35%), and other (chemical/electric/radiation) comprising 22%. Flame burns were found to have a significant impact on LOS (p = 0.039), requiring longer hospital stays compared to other burn sources. Age was a significant predictor, with each additional year of age associated with an increase of 0.15 days in LOS (95% CI: 0.05 to 0.25, p < 0.001). Similarly, the total body surface area (TBSA) showed a significant positive association, with larger burn areas strongly predicting longer hospital stays (p < 0.001). The median TBSA was 5.5% (SD ± 6.7). For every 1% increase in TBSA burns, the hospital stay increased by approximately 0.13 days (95% CI: 0.05 to 0.22, p < 0.05). However, variables such as inhalation injury (p = 0.748) and BMI (p = 0.058) did not significantly predict hospital duration.
Conclusion: The results of this study demonstrated that age, burn severity, and the source of the burn are significant predictors of prolonged hospital stay in pediatric burn patients. Recognizing these key predictors of LOS will allow providers to identify high-risk patients early and initiate prompt stabilization, management, and timely referral to tertiary centers when necessary. Further, the results of this study may serve as the framework for the development of preventative efforts and regional care guidelines for rural, underserved healthcare providers.
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http://dx.doi.org/10.7759/cureus.77589 | DOI Listing |
J Immunol
February 2025
Division of Pulmonary, Critical Care and Sleep Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
The erythroblastic island (EBI) functions as a niche in which erythroblastic island macrophages (EBIMφs) are positioned within rings of erythroblasts, providing support and signals that orchestrate efficient erythropoiesis. We postulated burn injury impacts the EBI niche, given the nearly universal presence of anemia and inflammation in burn patients, and a divergent myeloid transcriptional signature that we observed in murine bone marrow following burn injury, in which granulocyte colony-stimulating factor (G-CSF) secretion broadly attenuated the expression of EBIMφ marker genes. Notably, we identified the heme-induced transcription factor Spi-C as a robust marker of EBIMφs in Spicigfp/igfp mice.
View Article and Find Full Text PDFEur J Paediatr Neurol
March 2025
School of Psychology, University of East London, London, UK. Electronic address:
Background: Neonatal Hypoxic-Ischaemic Encephalopathy (HIE) increases the risk for neurodevelopmental impairment. Information on school-age memory function is limited in children who received hypothermia treatment (TH) for neonatal HIE.
Objectives: To evaluate memory function in school-aged children who had neonatal HIE and TH and survived without major neuromotor impairment.
Burns
January 2025
Department of Pediatric Surgery, Altona Children's Hospital, Hamburg, Germany; Department of Pediatric Surgery, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Comittee of the German Burn Registry, Germany. Electronic address:
Background: Fluid resuscitation after a burn injury is one of the crucial aspects of acute therapy. The Parkland formula is a quick solution for determining the amount of fluid necessary in a specific situation, although it is not strictly followed or used in current practice. Therefore, we aimed to assess the association between a deviation from the Parkland formula and in-hospital mortality.
View Article and Find Full Text PDFJ Clin Psychol Med Settings
March 2025
Boston Children's Hospital, Boston, USA.
The health disparities experienced by gender-diverse youth have not yet been adequately examined within specific pediatric populations, such as chronic pain. Furthermore, such disparities need to be examined within the context of the COVID-19 global pandemic, a time when clinicians observed an increase in gender-diverse patients seeking care for pediatric chronic pain. The goal of this study is to better understand the clinical pain-related and psychosocial presentation of gender-diverse youth who sought treatment for chronic pain prior to and following the start of the COVID-19 pandemic.
View Article and Find Full Text PDFCureus
February 2025
Plastic and Reconstructive Surgery, Hull University Teaching Hospitals National Health Service (NHS) Trust, Hull, GBR.
Burn injuries in the paediatric population are common and account for a substantial proportion of hospital attendances, leading to a growing focus on optimising wound care to enhance healing, reduce discomfort and minimise the need for frequent dressing changes. Traditional dressings for superficial burns in children have inherent limitations that may hinder these goals. Biobrane (Dow Hickman/Bertek Pharmaceuticals, Sugar Land, TX), a semi-permeable silicone device embedded with a nylon mesh and a porcine-derived collagen matrix, offers a promising alternative with advantages such as improved wound healing, reduced pain and fewer dressing changes.
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